Endocrine Abstracts

Introduction: Turner Syndrome is a genetic disorder linked to the total or partial absence of an X chromosome. The clinical presentation is heterogeneous, associating a small stature with a dysmorphic syndrome that varies from one person to another.

The aim of this study was to determine the prevalence of autoimmune diseases in our Turnerian patients.

Material and method: This is a retrospective descriptive study collecting 15 cases of Turnerian patients followed in the Endocrinology-Diabetology and Nutrition Department of the Mohammed VI University Hospital Center of Oujda, Morocco.

Results: The mean age of diagnosis was 12.2 13.1 years. Only 33.3% of cases were diagnosed in childhood. Short stature was objectified in 40% of cases, followed by primary amenorrhea in 26.7% of cases. Four patients had peripheral hypothyroidism (26.7%). Hashimoto was noted in 2 cases. Celiac disease was diagnosed in 2 patients, and type 1diabetes in one case. Psoriasis was diagnosed in one patient.

Conclusion and discussion: Autoimmunity has been recognized as one of the most important characteristics of Turner syndrome. Turner patients have an increased risk of developing in particular: Hashimoto’s autoimmune thyroiditis, celiac disease, type 1 diabetes, psoriasis and rarely Basedow’s disease. The results of our study are consistent with those reported in the literature; the frequency of these pathologies requires systematic screening at the time of diagnosis and during surveillance.