Endocrine Abstracts

Introduction: Turner’s syndrome (TS) affects 1/2500 female births and it is characterized by growth retardation, dysmorphic syndrome and gonadal dysgenesis. Our objective was to describe the clinical, therapeutic and evolutive features of Tunisian patients with TS.

Patients and Methods: It was a retrospective study including 23 patients with TS diagnosed between 1993 and 2019.We noted clinical, therapeutic and evolutive data for each patient.

Results: The average age at diagnosis was 17 years (10–33 years). The karyotype showed a 45 × 0 monosomy (n = 13), a mosaicism without structural abnormality (n = 6) or a mosaicism with structural anomaly (n = 3). Our patients consulted for growth retadration (n = 9) and amenorrhea (n = 14). Twenty-eight percent of them had an history of otitis. Dysmorphic syndrome was present in 20 patients with a pathological cardiovascular examination in 2 patients. Hypothyroidism was noted in 6 patients, celiac disease and hyperthyroidism (Graves’ disease) in one patient. Growth hormone (GH) therapy was started in 9 patients, for other patients advanced age was a limiting factor for treatment. The final height was greater in the patients having received GH treatment (P = 0.01). The mean age of induction of puberty was not delayed in the patients who received GH (P = 0.384). Spontaneous menarche was noted in one patient who had a mosaic karyotype without structural abnormalities.

Conclusions: The diagnostic of TS is very late in our country. GH treatment has a significative effect on the final height but it must be established in childhood. We have to think about TS in case of dysmorphic syndrome or statural delay in young girls.