ECE2020 ePoster Presentations Reproductive and Developmental Endocrinology (37 abstracts)
Thyroid peroxidase antibodies in women with polycystic ovary syndrome and type 1 diabetes
Agnieszka Lebkowska 1 , Agnieszka Adamska 2 , Anna Krentowska 1 , Aleksandra Uruska 3 , Anita Rogowicz-Frontczak 3 , Aleksandra Araszkiewicz 3 , Justyna Hryniewicka 2 , Monika Leśniewska 4 , Katarzyna Ożegowska 5 , Ewa Wender-Ożegowska 6 , Dorota Zozulinska-Ziolkiewicz 3 & Irina Kowalska 1
1Medical University of Bialystok, Department of Internal Medicine and Metabolic Diseases, Poland; 2Medical University of Bialystok, Department of Endocrinology, Diabetology and Internal Medicine, Poland; 3Poznan University of Medical Sciences, Department of Internal Medicine and Diabetology, Poland; 4Medical University of Bialystok, Department of Reproduction and Gynecological Endocrinology, Poland; 5Poznan University of Medical Sciences, Department of Infertility and Reproductive Medicine, Poland; 6Poznan University of Medical Sciences, Department of Reproduction, Poland
Objective: Polycystic ovary syndrome (PCOS) is more prevalent among women with type 1 diabetes (T1DM) than in general population. Autoimmune thyroiditis (AIT) is the most common autoimmunological disease in young women in reproductive age, especially in T1DM. Data in literature indicate the possible role of thyroid autoimmunity in PCOS pathogenesis. It has been suggested that positive concentration of thyroid peroxidase antibodies (TPOAbs) is associated with increased prevalence of PCOS. Data in women with PCOS and T1DM are not known. The aim of this study was to evaluate the presence of TPOAbs and its relationships with clinical and laboratory parameters in women with PCOS and T1DM.
Patients and Methods: We studied 83 women with T1DM (age 26 ± 5 years, BMI 24 ± 3 kg/m2): 41 with PCOS and 42 without PCOS. PCOS was diagnosed using the Rotterdam criteria. Anthropometric measurements, clinical parameters, ultrasonographic evaluation of the ovaries, assessment of serum concentrations of sex hormones, TPOAbs, TSH, free triiodothyronine and free thyroxine were performed for all women.
Results: In PCOS women, we found 12 women with positive serum concentration of TPOAbs (T1DM + PCOS + TPOAbs) and 29 women with negative serum TPOAbs (T1DM + PCOS + noTPOAbs); in the group without PCOS, 18 had positive serum TPOAbs. The prevalence of positive TPOAbs concentration did not differ between women with and without PCOS. Groups T1DM + PCOS + TPOAbs and T1DM + PCOS + noTPOAbs did not differ in anthropometric measurements, daily dose of insulin, or HbA1c. TSH and free thyroid hormones, as well as hormonal profile were comparable in T1DM + PCOS + TPOAbs and T1DM + PCOS+noTPOAbs. In all PCOS women, TPOAbs concentration correlated significantly with hirsutism score (r = 0.48, P = 0.001) and ovarian volume (r = 0.33, P = 0.037).
Conclusions: In T1DM women, PCOS is not related to higher prevalence of positive serum TPOAbs detection.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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