Endocrine Abstracts

Introduction: Limited data exist on testosterone and oxidative stress induction. The present study was undertaken to evaluate, in vitro, the role of physiological concentrations of androgens (testosterone-DHT) in modulating the pro-oxidant and antioxidant activity of intact endothelial cells.Materials and methods: EA.hy926 macroendothelial cells were cultured in DMEM phenol red free without FBS for 24 hours. Growth medium was replaced and then testostero...

We made a retrospective study of X monosomy cases identified in our laboratory in the last 10 years. The aim of study was to establish a correlation between different forms of X monosomy, and age for confirmation of cytogenetic diagnosis. Between 2010 and 2019 we confirmed 81 cases of Turner syndrome in our laboratory. We found different forms of X monosomy and the most frequent was X homogenous X monosomy. We found 24 cases (29.62%) of X homogenous monosomy (median age of dia...

Objective: Polycystic ovary syndrome (PCOS) is more prevalent among women with type 1 diabetes (T1DM) than in general population. Autoimmune thyroiditis (AIT) is the most common autoimmunological disease in young women in reproductive age, especially in T1DM. Data in literature indicate the possible role of thyroid autoimmunity in PCOS pathogenesis. It has been suggested that positive concentration of thyroid peroxidase antibodies (TPOAbs) is associated with increased prevalen...

Introduction: Studies investigating the association between serum IGF-1, and thyroid nodule, ovarian or thyroid volume in polycystic ovarian syndrome (PCOS) are limited. We aimed to analyze the association between serum IGF-1 level, and ovarian or thyroid volume, or thyroid nodule in PCOS.Materials and methods: The study was performed between June 2017 and August 2019 as prospective design. The patients referred to our medical faculty were included. Adul...

Introduction: Transsexuality is defined as discordance between one’s assigned sex at birth and that individual’s gender identity. Hormonal, anatomical, legal and psychosocial adaptations are present in most cases. Following recent changes to the Spanish legal framework, modifications have instaured to the model of attention for transsexual people in Andalusia. The aim of this study was to evaluate healthcare demand evolution in Trans People Attention Unit of Puerta...

Considered as the biggest public health problem, the pandemic growth of obesity is associated to decline of male fertility potential over the last 50 years. Thus far, the effect of weight loss on semen parameters is still controversial and poorly understood. In this study we report the effect of significant weight loss on semen parameters of two obese men with metabolic syndrome. The patients followed to a very low-calorie ketogenic diet (VLCKD) according to a commercial weigh...

Obesity is the single most significant risk factor for testosterone deficiency in men, with a reported prevalence up of 60% of male obesity secondary hypogonadism (MOSH). Several studies have shown that significant weight loss due to bariatric surgery have significant metabolic and endocrine improvement in obesity, however the results achieved with conventional diet and lifestyle change are poor and not able to reverse this condition. As an alternative to bariatric surgery, we...

Introduction: 46, XX male syndrome–testicular disorder of sexual differentiation (DSD) is a rare condition, that was first described by la Chapelle et al. in 1964. The phenotypes of 46, XX testicular DSD include males with normal phenotype, males with genital ambiguities or males with true hermaphrodites. The diagnosis may be more difficult in adults with normal gender development than in children. Here, we present hormonal and cytogenetic conditions of an adult male who...

Introduction: The role of thyroid hormones is important in testicular development and function (involvement in Sertoli cell proliferation and functional maturation control and postnatally in Leydig cell differentiation and steroidogenesis). Additionally, thyroid hormone receptors are found in testicular cells throughout development and in adulthood. Our aim was to study thyroid hormone effects on testicular function.Materials and methods: We retrospectiv...

Introduction: There have been described that about 50% of women diagnosed with PCO-S, present lipid metabolism disorders, insulin resistance and incorrect blood pressure. They suffer not only from fertility disorders, but also present a risk of metabolic complications such as: obesity, type 2 diabetes and hypertension, which increase diet-related cancers and cardiovascular risk.Aim: To explore if serum omentin concentration could be an indicator of cardi...

Introduction: Turner syndrome is one of the most common chromosomal abnormalities, with a reported prevalence of one in every 2.500 live-born girls. The phenotype includes short stature, primary ovarian failure, and other characteristics resulting from the consequences of fetal lymphedema and skeletal abnormalities. Turner syndrome can be associated with multiple defects: cardiovascular, renal, auditory, and skeletal. The aim of our study was to detect the prevalence of cardia...

Introduction: Leydig stromal cell tumors are a subtype of steroid tumors that make up to less than 0.1% of the ovarian tumors. These neoplasms can affect women from all ages but are more frequent after menopause, being usually unilateral, benign and small sized. In around 75% of cases, these tumors produce androgenic hormones, causing oligomenorrhea and virilization.Case report: A 39-year-old woman, nulligravid, with complains regarding androgenic alopec...

Introduction: Leydig cell tumors (LCTs) are uncommon neoplasms arising from gonadal stroma, accounting for 1–3% of all testicular tumors in adults. The etiology of LCT remains unclear. About 25% of LCTs secrete predominantly estrogens, which produce gynecomastia.Observation: We report a case of a 53-year-old male patient who sought evaluation for bilateral gynecomastia. He had a long-term use of amitriptyline and benzodiazepine. The physical examin...

Introduction: Hirsutism is a condition featuring an excessive growth of terminal hair at the woman’s androgen-dependent areas, which develops in a distribution model similar to that of men. It is one of the most common disorders in women during reproductive age. It affects up to 1 in 7 women. The objective of this work was to study the clinical and etiological aspects of hirsutism.Material and Methods: This is a retrospective descriptive study invo...

Introduction: Recent studies report the presence of KLK3 in women serum, KLK3 is excreted by Skene glands, it is involved in the production of cervical-vaginal fluid (CVF). Activation of KLK3 is pH depending, it has been hypothesized to have antimicrobial, immuno-regulator activity and vaginal and cervical epithelial desquamation. We intend to verify if KLK3 is present in female serum, in which menstrual cycle phases KLK3 ...

Introduction: The aim of this study was to investigate the association between the genetic background of coagulation factors and the presence of oligo- or amenorrhea in adolescent girls diagnosed with anorexia nervosa compared with controls.Patients and Methods: A total of 40 adolescent girls diagnosed with anorexia nervosa aged 14–17 years, as well as 10 age-matched girls, were included in the study. We recorded anthropometric parameters and calcu...

Introduction: Polycystic ovary syndrome is the most frequent ovarian dysfunction during the reproductive period. Its presence significantly impacts on the final scores of various Quality-of-Life (QoL) questionnaires. This pilot study aims to analyze the impact of hirsutism (H), as the component of PCOS, on the scores of determined generic (General Health Questionnaire-12, GHQ12) and disease-specific questionnaires (Polycystic Ovary Syndrome Questionnaire, PCOSQ) in PCOS subjec...

Introduction: The level of anti-Mullerian hormone (AMH) is considered by several authors as a marker of polycystic ovary syndrome (PCOS). However, data are lacking regarding the real role of AMH and its cut-off value for predicting the existence of PCOS in women with morbid obesity.The aim of this study was to analyze the performance of the AMH assay in the diagnosis of PCOS in women with morbid obesity.Patients and Methods: We con...

Introduction: Turner’s syndrome (TS) affects 1/2500 female births and it is characterized by growth retardation, dysmorphic syndrome and gonadal dysgenesis. Our objective was to describe the clinical, therapeutic and evolutive features of Tunisian patients with TS.Patients and Methods: It was a retrospective study including 23 patients with TS diagnosed between 1993 and 2019.We noted clinical, therapeutic and evolutive data for each patient.<p ...

Introduction: The fact that up to 33% with type 2 diabetes develop hypogonadotropic hypogonadisms (HH), are still not catching enough attention. More futher ’’the 5-year mortality of somebody who has got diabetes, who has had a myocardial infarction is actually lower than the diabetic patient who has developed a diabetic foot ulcer, which is around 48%’’.Case description: We describe male patient, 47 y. (on 2016y), newly diagnosed...

Introduction and aimGraves’ disease which is the most common cause of hyperthyroidism is an autoimmune disease presenting with goitre, orbitopathy and dermopathy. The disease is caused by stimulant type TSH receptor antibodies (TRAB). TSH receptor (TSHR) has been shown in different tissues other than thyroid. Testis is one of the extrathyroidal tissues with TSHR. The aim of this study was to investigate relationship between TRAB and inhibin-B, whic...

Introduction: Postmenopausal virilization with acute onset and rapid progression requires a thorough investigation for the presence of adrenal or ovarian tumor. We present here a challenging case of a radiologically not visible and rare androgen-hypersecreting ovarian tumor.Case report: A 71-year old postmenopausal woman presented to our department for the investigation of terminal hair growth, of recent onset and rapid progression, on the upper lip, chi...

Introduction: Leydig cell tumors (LCT) are rare testicular tumors, characterized by mostly benign etiology. Due to their secretory activity androgen- and/or estrogen-excess can occur.Case report: A 42-year old patient with recent history of cerebrovascular incident was admitted to the hematology department for diagnostic work-up of new-onset erythrocytosis (hemoglobin 185 g/l [reference 127–163], hematocrit 0.53 [0.37–0.46]). Myeloproliferati...

Introduction: Turner Syndrome is a genetic disorder linked to the total or partial absence of an X chromosome. The clinical presentation is heterogeneous, associating a small stature with a dysmorphic syndrome that varies from one person to another.The aim of this study was to determine the prevalence of autoimmune diseases in our Turnerian patients.Material and method: This is a retrospective descriptive study collecting 15 cases ...

Purpose: The use of anabolic androgenic steroids (AAS) to improve fitness and increase muscle mass is widespread among athletes. Information regarding self-administered AAS used to enhance athletic performance or improve physical appearance is sparse and poorly documented in Saudi Arabia. The purpose of this study is to investigate the prevalence and motivation of AAS use and knowledge of its adverse effects among fitness centres visitors in Eastern Province, Saudi Arabia....

The aim of the study was to assess the role of the estradiol and progesterone relationship during the late luteal phase and the occurrence of fibrocystic breast disease (FBD). The concentration of E2/P was measured in the group of women with FBD as study group and healty control group. All women had regular ovulation cycles. Blood samples for E2, P and prolactin determination were obtained in the morning at 8 am on days 21 and 24 of menstrual cycle. Significant mastalgia and m...

Introduction: Insulin resistance (IR) is the main pathogenic factor in polycystic ovary syndrome (PCOS) and its complications. Ceylon cinnamon (CC) is an herb with an insulin-sensitizing effect reported in diabetic patients.The aim of our study was to assess the efficiency of CC on the parameters of the IR in patients with (PCOS).Methods: We conducted a prospective interventional study, we included 13 patients with PCOS diagnosed according to the Rotterd...

Introduction: Recent studies report the presence of KLK3 in women serum, KLK3 is excreted by Skene glands, it is involved in the production of cervical-vaginal fluid (CVF). Activation of KLK3 is pH depending, it has been hypothesized to have antimicrobial, immuno-regulator activity and vaginal and cervical epithelial desquamation. We intend to verify if KLK3 is present in female serum, in which menstrual cycle phases KLK3 ...

Objective: Sperm cells are produced in the testes by the Sertoli cells. These cells produce Inhibin B and they are stimulated by FSH. Can Inhibin B be a good marker of spermatogenesis? Should we use other marker (FSH?, testosterone?)Design: Prospective study.Patients: We examined 71 patients with infertility.Methods: Semen analysis and hormonal analysis was performed. Semen analysis was performed according to...

Chronic kidney disease (CKD) is a global burden, with prevalence of 11–13%. CKD usually remains asymptomatic until later stages, but is strongly associated with increased risks of cardiovascular morbidity, premature mortality and decreased quality of life. Kidney transplantation (KT) is a treatment of choice for end stage CKD. KT was performed 350 times from dead donor and 6 times from living donor in the GU ‘Minsk Scientific-Practical Center of Surgery, Transplant...

We study the impact of the dehydroepiandrosterone (DHEA) by the women with diminished ovarian reserve and very low DHEA-S in the blood.Patients: We present a description of 7 patients with diminished ovarian reserve (DOR). Patients reported because of problems with getting pregnant. Infertility lasted for several years. The patients disagreed on IVF for ethical and religious reasons. All of the presented patients were diagnosed with diminished ovarian re...

Background: Hypogonadism is common among human immunodeficiency virus (HIV)-infected men. The actual prevalence remains poorly defined and ranges from less than 10% to over 50% in different studies. Secondary hypogonadism is the most common cause of hypogonadism among HIV-infected men. In hypogonadal HIV-infected men, naive of highly active antiretroviral therapy (HAART), around 75% have secondary hypogonadism due to the suppression of gonadotropins by the active inflammation ...

We present a 37-year-old gentleman (Mr. A) who self-referred to the endocrine clinic for review of his testosterone replacement therapy.He required testosterone replacement therapy aged 11 years old following surgical removal of underdeveloped testes of unknown aetiology. He was prescribed testosterone injections until the age of 22 years old when testosterone patches were trialled, which he did not tolerate. He commenced testosterone replacement gel (TE...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a monogenic, dominantly inherited disorder caused by mutations in the MEN1 gene. Unfortunately, the outcome and the patients’ prognosis are unpredictable even among members of one family. It seems clear that other factors influence the individual outcome of the disease. However, it is still unclear what kind of factors (genetic or environmental) would be responsible for the observed differences.<p c...

Brain tumors are on the 3rd place in terms of growth rates of incidence among oncological diseases. By virtue of the improvement of neurosurgical treatment methods, with the use of modern chemotherapy and radiation therapy, the survival of patients with benign and malignant brain tumors is increasing. A significant proportion of patients with such tumors are young people of reproductive age who are interested in maintaining their fertility. Neurosurgical removal of tumors, whi...

The aim of investigation to examine characteristics of true premature sexual development in children and adolescents over three years.Material and Methods: We observed 9 children with true premature sexual development (including boy – 1, girls –8), which had treatment in the pediatric department of the Center of Endocrinology in the period from September 2016 to July 2018 years. Patients were measured height, weight, considered a lack of grow...

The aim of investigation to study the prevalence rate of precocious puberty (PP) in children by region of the Republic of Uzbekistan (as of December 31, 2018). The prevalence rate of premature sexual development in children by region of the Republic of Uzbekistan (as of December 1, 2018).Material and Methods: We observed 173 children with true precocious puberty (including boy – 51, girls – 122), which had treatment in regional endocrinology ...