ECE2020 ePoster Presentations Pituitary and Neuroendocrinology (94 abstracts)
Cardiovascular risk factors in acromegaly: comparison between successful surgery with medical treatment
Nerea Egaña Zunzunegui , Ismene Bilbao , Cristina García , Maite Aramburu , Leire Agea , Izaskun Olaizola , Jorge Rojo , Alfredo Yoldi & Miguel Goena
Hospital Universitario Donostia, Endocrinology, Spain
Introduction: Acromegaly is an insidious disease caused by chronic GH and IGF-I hypersecretion associated with increased morbidity and mortality, mostly from cardiovascular complications. The aim of this study is to compare cardiovascular risk factors, between patients with medical treatment vs cured.
Materials and methods: This is a retrospective study of 37 acromegalic patients, 21 well controlled with medical treatment (IGF-I within the normal range for age and sex) and 16 cured after successful surgery and/or radiotherapy. Studied cardiovascular risk factors are: BMI, glucose metabolism, dyslipemia and hypertension. Of those on medical treatment, 57% received depot somatostatin analog (SST), 5% pegvisomant, 5% cabergoline, and rest SST with cabergoline. No cardiovascular event was observed.
Results: There is no significant differences in age at diagnosis, GH and IGF-I levels, and current IGF-I index. There are more hypopituitarism in the cured group despite no differences in radiotherapy. The number of macroadenomas, patients with dyslipemia and basal glycemia disturbances are significantly higher in the “not cured” group, however there is no differences in diabetes mellitus.
| Curados | TTO Medico | P | |
| Age | 57.7 | 59.86 | ns |
| Age at diagnosis | 39.6 | 45 | ns |
| Sex (F/M) | 56.3/43.8 | 47.6/52.4 | |
| Macro/Micro | 75/25 | 90.5/9.5 | P < 0.05 |
| Surgery | 100% | 81% | P < 0.05 |
| Radiotherapy | 37.5% | 33.3% | ns |
| Hypopituitarism | 62.5% | 42.9% | P < 0.05 |
| GH at diagnosis | 22.5 | 21.3 | ns |
| IGF-I at diagnosis | 750.17 | 811.88 | ns |
| IGF-I index at diagnosis | 5.61 | 5.93 | ns |
| Current IGF-I index | 1.52 | 0.97 | ns |
| BMI | 27.47 | 28.7 | ns |
| Hypertension | 43.8% | 38.1% | ns |
| Dyslipemia | 50% | 71.4% | P < 0.05 |
| Basal glycemia disturb | 6.25% | 23.8% | P < 0.05 |
| DM | 18.8% | 14.3% | ns |
Conclusion: A good hormonal control can be achieved with current medical treatments. We demonstrated that cardiovascular risk is similar in both groups. Therefore, strict hormone control is required to improve the cardiovascular prognosis in patients with acromegalia.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more