Endocrine Abstracts

Benign prostatic hyperplasia and prostate cancer are androgen-dependent diseases. Dihydrotestosterone (DHT) is a 5α-reduced metabolite of testosterone (T), which is the causative factor for the progression of these diseases. The 5α-reductase enzyme (5α-R) converts T to DHT, which is responsible for increasing cell proliferation, and hence inhibition of this enzyme could lead to potential treatments for these afflictions. This study aimed to determine the biologi...

Introduction: Limited data, support the notion that testosterone induces oxidative stress. Corticotropin-releasing hormone (CRH) participates locally in the endothelial inflammatory response by regulating the pro-oxidative mechanisms of the endothelium, inducing its adaptation to local stress. The present study was undertaken to determine whether the CRH induced pro-oxidant activity in macroendothelial cells under basal conditions, is regulated In vitro by androgen (t...

Medical students around the globe undergo serious amounts of stress related to adjustment to the rigors of medical curriculum, to change of roles, and other factors intrinsic to medical education. Research has shown that stress among medical students is associated with generally lower academic performance and lower job satisfaction once physicians. The goal of this study was to analyze the influence of healthy lifestyle practices not only on medical students’ health over...

Introduction: Endocrine disorders and kidney diseases can coexist. Some of these have a common pathophysiological background. Strategies for treating endocrinopathy or glomerulonephritis (GN) may affect the function of the endocrine system and kidney.Aim: The study was aimed to assess the correlation of kidney biopsy results performed in people with suspected GN with thyroid function, metabolic syndrome and diabetes occurrence.Mate...

Old people will have to take care of themselves as long as possible. The challenge for the future is therefore not to extend human age at all costs, but to extend human self-sufficiency. Two years ago, we showed that patients with anxiety and affective disorders (‘depression’) felt great after a month’s stay at the spa, improved in a number of endocrinologic parameters. In this work we try to explain the physiological changes of stay in a spa without pharmace...

Abstract: Gliomas of the optic pathways are rare tumors that are mainly seen in children. We report the case of a 4 year old boy followed since the age of 6 months for a nystagmus. It is a boy born at term by vaginal way resulting from parents not consanguineous, the parents noted the nystagmus when their child was 6 months old. After opinion of the ophthalmologist, the child is treated only by optical correction, it is only at the age of 4 years following the installation of ...

Recently, special attention has been paid to the relationship between doctors and the pharmaceutical industry. The aim of this work was to evaluate the attitude of Tunisian endocrinologists towards pharmaceutical promotion.Methods: It was a cross-sectional study based on an anonymous 9-item survey about the attitudes and behaviors of physicians towards the pharmaceutical promotion. The study included 120 participants.Results: One-t...

A 66-year-old patient was diagnosed with lung cancer. In the interview, smoking for 40 years, about 20 cigarettes/day. Due to the intensifying cough, an x-ray of the chest was performed, a large tumor (12 cm) of the mediastinum and the right cavity was found. In the histopathological examination squamous cell carcinoma. Stage T4 N2 M0. Due to tumor inoperability, the patient was qualified for sequential chemo-radiotherapy. He received 3 cycles of chemotherapy (navelbin and cis...