Endocrine Abstracts

Introduction: Disorders of glucose metabolism are often present in chronic liver diseases. The aim of our study is to determine the prevalence and factors associated with type 2 diabetes in patients with cirrhosis.

Methods: This is a retrospective study collecting all patients with cirrhosis between January 2010 and December 2019.

Results: During the study period, 166 patients were included. Of these patients, 47 patients had type 2 diabetes (28.3%). These were 29 women and 18 men with an average age of 61.6 years (between 17 and 84 years). Cirrhosis was metabolic in 18 cases (38.3%), viral B in 9 cases (19.1%), viral C in 8 cases (17%), autoimmune in 5 cases (10.6%), of alcoholic origin in 4 cases and of undetermined etiology in 3 cases. Cirrhosis was classified as CHILD A in 16 patients (34%), CHILD B in 23 patients (49%) and CHILD C in 8 patients (17%). Ascitic decompensation was present in 33 cases (70.2%). Six patients (12.8%) had hepatic encephalopathy. Forty-four patients (93.6%) had esophageal varices on upper gastrointestinal endoscopy. Cirrhosis was complicated by hepatocellular carcinoma (HCC) in 5 patients (10.6%). Analytic study had shown that the presence of type 2 diabetes was associated with older age (P = 0.018), metabolic origin (P = 0.001) and viral B origin (P = 0.04). However, there was no association with gender, the severity of cirrhosis, and the presence of HCC.

Conclusion: In our study, type 2 diabetes was present in 28.3% of cirrhotic patients and it was associated with advanced age, metabolic and viral B origin.