Endocrine Abstracts

Background: Obesity is worldwide epidemics and the main risk factor for many diseases. Traditional methods of prevention and treatment of obesity often unfavorable and patients undergo to alternative treatment such as bariatric surgery. To better understanding the pathogenesis of obesity, we aimed to analyse the main abnormalities in blood serum in patients accepted to bariatric surgery.

Material and Methods: 27 patients (13 men and 14 women) with obesity after unfavorable treatments were accepted to bariatric surgery. In both group blood fasting and postprandial glycemia, HbA1c level, serum creatinine (Crea), fibrinogen (Fib), ALAT, ACAT, bilirubin, blood urea nitrogen levels, prothrombin index (PTI), lipids level such as Triglycerides (TG), Cholesterol Chol), LDLP, HDLP were measured and compared.

Results: Showed that even average ages were similar in men and women (37 years old), BMI was higher in men (48.09 ± 9) than in women (38.85 ± 5.85). Blood bilirubin (by 1.3 times), Crea (by 1.6 times), ALAT (by 2.1 times) levels were higher in men than in women and showed linkage with BMI. Although the blood coagulation assessed by Fib and PTI, and blood lipids assessed by TG, Chol, LDLP, HDLP levels, as well as the atherogenic coefficient were comparable in both groups, impaired glycemia was determined in 62% of man and in 46% woman. These results suggest that obesity degree, and its metabolic abnormalities were more severe in men than in women.

Conclusion: Metabolic abnormalities were more severe in men than in women with obesity accepted to bariatric surgery after unfavorable treatment and differs by higher BMI, higher blood bilirubin, Crea, ALAT level and more cases of impaired Glycemia (62% vs 42%).