Endocrine Abstracts

Introduction: Vitamin D has pleiotropic effect on human body. Several studies showed that vitamin D deficiency has an influence on inflammation status in endocrine diseases (PCO-S, Graves disease, autoimmune endocrine disorders) and could reflect body fat tissue contain. Both, resistin and leptin, show pro-inflammatory effect.

Aim: The aim of the study was to asses resistin and leptin serum concentration and its relationship with 25-OH vitamin D concentration in patients with non-functioning adrenal incidentalomas.

Material and Methods: 25 patients hospitalized in Endocrinology City Hospital in Piekary in 2015 with non-functioning adrenal incidentalomas were inclued to the study. The exclusion criteria were: other adrenal disorders, decompensated diabetes defined as HBA1C% > 7, kidney failure as eGFR < 60 ml/min/1.73 m², liver failure as bilirubin > 2 mg/dl, INR > 1.5 and albumins < 3.5 g/dl, severe inflammation, cancer therapy. Patients blood was centrifuged, serum obtained and the resistin and leptin concentration determined in duplicates by ELISA method, as per manufacturer’s recommendations. Data of vitamin D concentration was taken from patients medical record.

Results: In analyzed group of patients the average vitamin D concentration was 22.9 ng/dl, resistin 6.4 ng/ml and leptin 70.4 pg/ml, BMI 29.9 kg/m². With increasing vitamin D concentration, leptin serum concentration decreased (r = –0.56, P < 0.05) and resistin serum concentration was statistically higher (r = 0.68, P < 0.05). There was also positive correlation observed (P < 0.05) between leptin and anthropometric indicators: BMI (r = 0.82), WHtR (r = 0.73), BRI (r = 0.73), WC (r = 0.6), LAP (r = 0.48).

Conclusion: Serum 25(OH)D3 concentration in studied group was below range and defined as mild insufficiency. Vitamin D concentration correlates with leptin and resistin in patients with non-functioning adrenal incidentalomas. To confirm obtained results further studies are needed.