Endocrine Abstracts

In recent years, there has been an increase in patients with metabolic syndrome (MS), which is an urgent medical problem. The severity of the clinical manifestations of MS affects the quality of life of patients, while reducing physical and mental health. Obesity leads to anxiety and depressive disorders, neurosis–like conditions, which contributes to a worsening prognosis of the underlying disease.

The aim of the work was to assess the level of anxiety, depression and quality of life in patients with metabolic syndrome.

Methods: 30 patients with MS and 35 healthy volunteers were examined at the clinic of the Research Institute of Medical Problems of the North. Patients were examined, anthropometric indicators were determined (waist circumference, body weight, BMI) with an assessment of the quality of life (questionnaire SF–36, Russian version, Institute of Clinical and Pharmacological Research, St. Petersburg). The level of anxiety and depression was determined by the hospital anxiety and depression scale HADS (The hospital Anxiety and Depression Scale Zigmond A.S., Snaith R.P.).

Results: Most indicators of quality of life were statistically significantly different in patients with MS relative to the control group. A decrease in the average level of the parameters “physical functioning” by 17.3% (P < 0.05), “role–based functioning” by 31% (P < 0.05), and “general health” by 11.3% (P < 0.05), “vitality” by 13% (P < 0.05), “emotional functioning” by 50.1% (P < 0.05). The level of anxiety and depression in patients with MS corresponded to a subclinically expressed level, the level of depression exceeded the value of the control group by 18%.

Conclusion: Patients with MS are characterized by a decrease in quality of life indicators, subclinically expressed anxiety / depression. According to MAPI Research Institute, the goal of any treatment is to improve the quality of life of patients to the level of healthy individuals, therefore, for patients with MS, along with pathogenetic therapy aimed at weight loss, correction of psychological disorders is required, which will reduce the level of anxiety–depressive disorders and improve quality of life.