Endocrine Abstracts

Background of the study: There is lack of data in the Czech Republic on iodine status in patients suffering from diabetes mellitus type 1 (DM1) considered to be at risk of iodine deficiency.

Subjects and methods: A total of 54 males and 51 females ‒ median (25th, 75th percentile): age (years) 42 (31, 55); BMI 25.9 (23.3, 29.7); HbA1c (mmol/mol) 61 (51.2, 71.0) treated for DM1 were included in this cross–sectional study. In addition to iodine saturation determined as the concentration of iodine in the first urine sample of the day, we measured clinical, anthropometric, and biochemical parameters related to DM1.

Aims of the study: The main aims were to obtain for the first time information about iodine saturation in Czech patients with DM1; and to determine a) to what extent this saturation differs from the non–diabetic population, b) whether iodine saturation is related to selected clinical and laboratory parameters and characteristics of diabetic syndrome.

Results: Measured iodine levels were: median 152 µg/l, 25th percentile 117 µg/l, and 75th percentile 219 µg/l. More than 50% of iodine levels were within the optimal saturation range of 100–200 µg/l, while about 14% showed incomplete saturation (<100 µg/l), and 34% had increased saturation (>200 µg/l).

Multi–dimensional regression showed significant positive relationships (P < 0.01; an OPLS model explaining 9% of the variability) between ioduria and male sex, body weight and height, and serum creatinine levels, which to date have not yet been published in DM1 patients. Relationships to the other analyzed parameters (HbA1c, insulin dose, DM duration, body mass index, microalbuminuria, glomerular filtration rate, thyroid function and volume, thyroid autoimmune markers) were not significant.

Conclusions: We found that Iodine saturation in our DM1 patients were within the ICCIDD (WHO) recommendations for optimal/good saturation for the non–diabetic population. We believe that long–term efforts to deal with iodine deficit in the general population of the Czech Republic are responsible for the satisfactory iodine status of the DM1 patients as well.

We did not find any significant relationships between iodine saturation and characteristics of diabetic syndrome, but multi–dimensional regression analysis found a new, as yet. unpublished positive relationship between ioduria and male sex, body weight and height, and creatinine levels.

“Supported by MH CZ – DRO (Institute of Endocrinology – EÚ, 00023761)”.