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Endocrine Abstracts (2020) 70 EP111 | DOI: 10.1530/endoabs.70.EP111

ECE2020 ePoster Presentations Bone and Calcium (65 abstracts)

Bone quality is affected in acromegaly beyound insulin resistence

Patricia Christina Codreanu1, Alexandru Elena1, Oprea Theodor2, Nistor Irina1, Predescu Andrada1, Pascu Raluca1, Balea Ana Maria1, Iancu Mirela1, Giurgiuman Niculina1, Reghina Aura Diana1, 2, Martin Sorina1, 2, Albu Alice1, 2, Sirbu Anca1, 2, Fica Simona1, 2 & Barbu Carmen Gabriela1, 2


1Elias Emergency University Hospital, Endocrinology and Diabetes, Nutrition and Metabolic Diseases Department, Bucharest, Romania; 2Carol Davila University of Medicine and Farmacy, Bucharest, Romania


Introduction: Diabetes mellitus and acromegaly are both associated with an increased risk of fracture caused by altered quality of bone. TBS represents an important tool for assessment of bone microarchitecture.

Objectives: The aim of this study is to assess the bone deterioration through the trabecular bone score (TBS) and to compare TBS and Z score between 2 groups of patients: acromegaly and diabetes mellitus.

Methods: This retrospective study included 2 groups of patients diagnosed and monitored in our clinic. 17 patients with diabetes mellitus between 45–77 years old (63.88 mean age; 32.04 mean BMI) were compared with 10 patients with acromegaly between 51–77 years old (61 mean age; 29.94 mean BMI). We selected the acromegalic patients without diabetes mellitus. In acromegalic group 3 patients had osteoporosis, 3 osteopenia and 4 had a T score in normal range while in diabetes group 3patients had osteoporosis, 2 osteopenia and 11 had a T score in normal range. The One way Anova test, used to compare TBS and Z score in the 2 groups, showed a lower mean TBS and hip Z score in acromegalic patients than in diabetic patients (1.260 vs 1.358, 95% CI, P < 0.05 and –0.4 vs 1.22, 95% CI, P < 0.01). Mean lumbar spine Z score didn’t show any significant difference between the 2 groups. The limitation of our study is the small number of patients.

Results: Our study shows that acromegaly is associated with a lower TBS and hip Z score than diabetes mellitus which means that acromegaly represents an additional risk factor for altered bone quality, added to insulin resistance, despite the older age of diabetic patients.

Volume 70

22nd European Congress of Endocrinology

Online
05 Sep 2020 - 09 Sep 2020

European Society of Endocrinology 

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