ECE2020 ePoster Presentations Adrenal and Cardiovascular Endocrinology (58 abstracts)
Metastatic melanoma of unknown primary lesion presenting as bilateral adrenal incidentalomas
Miruna Anisia 1 , Teodora Teusan 1 , Mihaela Ciobotar 1 , Cristina Preda 1 , Maria Christina Ungureanu 1,2 , Mihai Danciu 2 , Cristian Lupascu 2,3 & Letitia Leustean 1,2
1Saint Spiridon County Hospital, Endocrinology, Iași, Romania; 2Universitatea de Medicină și Farmacie “Grigore T. Popa”, Iași, Romania; 3Saint Spiridon County Hospital, Surgery, Iași, Romania
Introduction: Bilateral adrenal incidentalomas represent a challenge both in diagnosis and therapeutic approaches. While initial testing is similar to unilateral adrenal incidentalomas, additional investigations should be made considering the differences between the distribution of etiologies.
Case report: We report the case of a 67 years old hypertensive female, presenting with backpain; an initial abdominal ultrasound described left adrenal mass and a large right adrenal/hepatic mass. The thoraco-abdominal CT scan revealed a well circumscribed right sided adrenal mass (105/95/110 mm AP/T/CC), hypodense compared with the liver parenchima, heterogenous and of low density on pre-contrast imaging, with progressive enhancement after contrast administration and mass effect on the adjacent kidney and right hepatic lobe; also, a similar lesion on the left adrenal gland of 61/45/60 mm and a right inguinal lymph node (27 mm). Hormonal assessments showed no secretion; congenital adrenal hyperplasia and adrenal insufficiency (giving the distruction of the cortex of both glands) were also ruled out. There was a rapid increase in inguinal lymph node size, so an excisional biopsy was made; the morphologic and immunohistochemical characteristics revealed lymph node metastasis of malignant melanoma (S100 intense positive in nucleus and cytoplasm, HMB45 intense positive in cytoplasm of tumoral cells). The patient was directed to Oncology Department and lost to follow-up.
Discussion: Adrenal metastasis are the most common malignant lesions involving the adrenal gland. On the other hand, bilateral adrenal masses due to melanoma metastasis are rare, usually nonsecretory, associated with short-term survival, being uncommon for metastatic cancer to appear in the adrenal gland before the primary lesion is known.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more