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Endocrine Abstracts (2020) 70 EP14 | DOI: 10.1530/endoabs.70.EP14

Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Málaga, Spain


Introduction: Adrenocortical carcinoma (ACC) is a very rare entity with a variable clinical presentation.

Objective: To review the casuistry of ACC in our center in the last 15 years and to assess clinical characteristics and evolution in our patients.

Material and method: We searched cases of ACC from 2004 to December 2018 registered in the Pathology Department.

Results: Fifteen cases were found, 9 women and 6 men. The mean age at diagnosis was 49.6 ± 12.7 years (range 27–82 years). The initial symptom was local discomfort (5), clinical hypercortisolism (4) constitutional syndrome (2), fortuitous (3), and unknown (3). Regarding location 8 were located on the right and 6 on the left gland. The size of the lesion at diagnosis was 11.15 ± 4.1 cm (range: 5.4–21 cm). Cortisol production was found in 7 cases. At the time of diagnosis, 4 had metastases (liver and/or lung). Only one case could not be intervened due to disseminated disease. After surgery, 5 developed local recurrence and 3 distant metastases. For 2 patients we do not have data regarding post-surgical evolution. Regarding need for post-surgical treatment: 4 patients were not treated for low aggressiveness, 1 for disseminated disease at diagnosis and 1 for post-operative death. 1 patient received adjuvant treatment with Mitotane and 5 Mitotane+etoposide, doxorubicin, and cisplatin (EDP). Only 3 patients have cure criteria today after more than 10 years of diagnosis, 7 patients with a mean survival of 9.3 months (range 3–12) have died, 1 patient has lost follow-up and 4 follow-up reviews of which 2 of them have metastatic disease (at 4 and 20 months post-surgery) and the other 2 are free of disease at this time (at 7 and 38 months post-surgery).

Conclusions: ACC is a very infrequent and aggressive entity in which is necessary to maintain an important degree of alertness and, above all, multidisciplinarity.

Volume 70

22nd European Congress of Endocrinology

Online
05 Sep 2020 - 09 Sep 2020

European Society of Endocrinology 

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