ECE2020 Audio ePoster Presentations Thyroid (144 abstracts)
Papillary thyroid cancer with biochemical incomplete response: Clinico-pathological characteristics and disease outcome
Miriam Steinschneider 1 , Mustafa Asly 1 , Efrat Markus 1 , Shlomit Koren 1 , Inna Tkacheva 1 , Carlos Benbassat 2 , Limor Muallem-Kalmovich 1 & Dania Hirsch 3
1Assaf Harofeh Medical Center, Zerifin, Israel; 2Shamir medical center, Tzrifin; 3 Rabin Medical Center, Petah Tikva, Israel
Objective: Althoughmost Papillary Thyroid Cancer (PTC) patients with biochemical incomplete response (BIR) to primary therapy have a good clinical outcome, some will develop disease progression. We aim to study baseline characteristics and long-term outcomes of PTC patients with BIR.
Methods: Of 1049 PTC patients treated at 2 tertiary medical centers, 795 (75.8%) had excellent, 91 (8.7%) biochemical incomplete, 139 (13.2%) structural incomplete and 24 (2.3%) indeterminate response one year after initial treatment. Clinical features, management and disease outcome of 91 BIR patients were evaluated. Mean follow-up was 11.8 ± 6.6 years.
Results: All patients underwent total thyroidectomy, 50.5% neck dissection and 97% RAI (122.4 ± 49 mCi). At diagnosis mean age was 48 ± 17 yr, 67% were females and 77% PTC. Mean tumor size was 25 ± 9 mm, with multifocality in 59.3%, ETE 8th in 24.4%, N1 in 43%, stage 8th in I-II 96.6%, and ATA low-risk 69.7%.No patient had distant metastases. Further treatment included: reoperation 20%, additional I131 52% (cumulative 278 ± 135 mCi). During follow-up 53.8% revert to no evidence of disease, 23.1% remained BIR and 23.1% progressed to structural disease. The switch to structural disease could be predicted by older age, ETE, higher ATA risk and advanced TNM 8th stage. PostOp stTg was not a predictor in BIR patients. At the study-end there were 8 deaths (3 disease-related).
Conclusions: Our data suggest that BIR patients have a generally favorable outcome, however up to 23% may progress to structural disease. In this preliminary study we found some variables to be considered as possible predictor factors
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more