Endocrine Abstracts

Relevance: Question of standards of iodine intake in pregnant and lactating women remains relevant.

Aim of study: to determine status and function of thyroid gland in pregnant and lactating women with and without antibodies to thyroid gland, on the background of taking different doses of iodine in 3 different regions of Russia with different iodine status.

Materials and methods: This study included 414 women in the different trimester of pregnancy (18–42 y.o.) and 256 newborns. They were divided into 2 groups: 1st group – women, receiving potassium iodide 200 mg/day, newborns breastfed from these women; 2nd group – women and newborns, receiving 300 mg/day.

Results: Initially, in all three regions, median iodinuria was below the threshold level (150 µg/l). After 3 months, a significant increase in the level of iodinuria in group 2 (96 µg/l at baseline and 259 µg/l at 3 months) was noted. Against the background of taking different doses, there was no increase of Anti-TPO. When comparing the iodine content of infants who are breastfed, there were no significant differences between the groups. Normal concentration of iodine in the urine was 58.6% in the newborns in the first group and 71% in the second group. The levels of TSH of newbornswere not statistically different; there were no increase above 5 mU/l.

Conclusions: We can say that in order to achieve optimal iodinuria, level of iodine intake should correspond to at least 250 µg/day. For now, initial urinary excretion of iodine does not correspond to normal iodine supply, which indicates the need for preconception treatment in regions with proven iodine deficiency. Study was carried out by RSF grant N17-75-30 035.