ECE2020 Audio ePoster Presentations Reproductive and Developmental Endocrinology (79 abstracts)
An assessment of the level of physiological stress in terms of release of cortisol, epinephrine, norepinephrine, prolactin and growth hormone and their relationship with ghrelin in normal and short stature children
Nighat Kausar 1 , Maleeha Akram 1 , Gulbin Shahid 2 , Afzaal Ahmed Naseem 3 , Mazhar Qayyum 1 , Faheem Tahir 4 , Sarwat Jahan 5 , Kiran Afshan 5 , Muhammad Rafi 6 & Syed Shakeel Raza Rizvi 1,7
1Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, Department of Zoology, Rawalpindi, Pakistan; 2The Children’s Hospital, Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan; 3University of Lahore, Sihala Campus, Islamabad, Pakistan; 4National Institute of Health, Reproductive Physiology, Public Health Laboratories Division, Islamabad, Pakistan; 5Quaid-i-Azam University, Department of Animal Sciences, Islamabad, Pakistan; 6Pakistan Institute of Engineering and Applied Sciences (PIEAS), Islamabad, Pakistan; 7University of Central Punjab, Quaid Campus, Rawalpindi, Department of Zoology, Rawalpindi, Pakistan
The short children have lower social competence and show more social problems than children with normal stature. The physical appearance has consequences in terms of how short stature children are judged and treated by others as they can be teased or bullied due to short stature, which may affect future prospects of finding a job or a spouse. These psychosocial stressors are risk factors for the psychological adjustment for children of short stature. Stress responses are activated by hypothalamo-pituitary-adrenal (HPA) axis by releasing cortisol, a marker of stress. Another hormone, ghrelin, also stimulates stress related HPA axis resulting in the release of cortisol. Both cortisol and ghrelin concentrations increase in parallel after psychological stress. The present study was designed to identify the level of physiological stress in terms of release of cortisol, epinephrine (E), norepinephrine (NE), prolactin (PRL), growth hormone (GH) and their relationship with ghrelin in normal and short stature children. ELISA was used for analysis of plasma cortisol, prolactin, E and NE and RIA was used for analysis of plasma GH of 50 normal school attending children and 35 short stature girls and boys. Data were analyzed using Student’s t test, ANOVA and Pearson correlation r. The concentrations of stress hormones such as cortisol, E and NE were higher in short stature children at puberty as compared to normal school attending children. The levels of GH and PRL were significantly decreased in short stature children than controls. In addition, the levels of plasma ghrelin were positively correlated with plasma cortisol, E, NE, GH and PRL levels in normal subjects while negatively correlated in short stature children. In conclusion, this study demonstrated higher concentrations of stress hormones, cortisol, E and NE in short stature children at puberty than normal school attending children indicating that short stature children were at a higher level of stress.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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