ECE2020 Audio ePoster Presentations Reproductive and Developmental Endocrinology (79 abstracts)
Prevalence and prognostic factors of dysglycemia in women with polycystic ovary syndrome: Findings from large caucasian cohort
Sarantis Livadas 1 , Christina Bothou 2 , Justyna Kuliczkowska-Płaksej 3 , Ralitsa Robeva 4 , Andromahi Vryonidou 5 , Jelica Bjekic Macut 6 , Ioannis Androulakis 1 , Zadalla Mouslech 7 , Andrej Milewicz 3 , Dimitrios Panidis 8 & Djuro Macut 6,9
1Metropolitan Hospital, Pireas, Greece; 2University Hospital of Zürich, Zürich, Switzerland; 3Uniwersytecka, Wrocław, Poland; 4Medical University-Sofia, Department of Endocrinology, Sofia, Bulgaria; 5Ερυθρός Σταυρός - Νοσοκοµείο “Κοργιαλενειο Μπενακειο” Ελληνικού Ερυθρού Σταυρού, Athina, Greece; 6University of Belgrade – Faculty of Medicine, Beograd, Serbia; 7AHEPA hospital, Thessaloniki, Greece; 8Aristotle University of Thessaloniki, Thessaloniki, Greece; 9Clinic of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia and Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Background: Insulin secretory defects and insulin resistance exists in women with polycystic ovary syndrome (PCOS) and are prerequisites for the development of type 2 diabetes (T2D). we aimed to determine the prevalence of T2D, impaired glucose tolerance (IGT) and impaired fasting glucose (IFG), as well as the factors associated with these dysglycemic conditions in this population.
Methods: 1614 PCOS women of Caucasian origin (Rotterdam criteria) with a mean age 25.14 ± 5.56 years and BMI 27.34 ± 7.09 kg/m2 comprised study group, whereas 359 normally ovulating, not hyperandrogenic women of comparable age and BMI, served as controls. This was an observational study and evaluation of biochemical/hormonal profile, ovarian ultrasound and as well oral glucose tolerance test was carried out in all studied subjects. Diabetes/intermediate hypeglycemia was categorized according to WHO criteria and PCOS subgroups was based on the Rotterdam criteria.
Results: In the PCOS group 2.2%, 9.5% and 12.4% of subjects had T2D, IGT and IFG, respectively. In control group 1.11%, 7.5% and 8.9% had T2D, IGT and IFG, respectively. When existence of T2D was stratified according to age and BMI, no difference was found among age and BMI subgroups or PCOS subgroups. In patients aged 17–22 years, T2D was detected in 3 lean and 2 obese subjects. The corresponding distribution for patients aged 22–30 years was 4 lean, one overweight and 2 obese, whereas in those older than 31 years, 2 overweight and 5 obese suffered from T2D. Free Androgen Index, waist to hip ratio and LDL levels were significantly higher in T2D compared to PCOS women with normal glucose metabolism. Diagnosis of T2D was significantly associated with Free Androgen Index (r: 0.469, P < 0.05), while subjects with either IFG and IGT had positive association with BMI, WHR, FAI and HOMA-IR. In controls, T2D, IGT and IFG were positively associated with BMI and androgen concentrations. Conclusions: The prevalence of T2D and IGT is significantly higher in our large cohort of PCOS women compared to controls. Existence of T2D is irrespective of age and BMI, and seems to be inherent for PCOS women. Hence, evaluation of glycemic status in PCOS women using OGTT is supported.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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