ECE2020 Audio ePoster Presentations Reproductive and Developmental Endocrinology (79 abstracts)
1Ghent University, Unit for Osteoporosis and Metabolic Bone Diseases, Department of Endocrinology and Reumatology, Ghent University Hospital, Ghent, Belgium, Ghent, Belgium; 2Ghent University, Department of Clinical Chemistry, Ghent University Hospital, Ghent, Belgium
Introduction: Although it is well-known that serum testosterone (T) levels decrease in ageing men, to this date no longitudinal data are available on changes in T levels in healthy young adult men.
Objective: To investigate age-related longitudinal changes in serum levels of total T, free T and sex hormone binding globulin (SHBG) in healthy young men.
Methods: Data from 999 healthy men aged 24–46years who participated in a longitudinal population-based sibling-pair study were included. After a mean follow up of 11.6 ± 1.9 (range 7–18) years, 709 participants were re-evaluated. SHBG, luteinizing hormone (LH) and follicle stimulating hormone (FSH) were measured using Roche e801 immuno-assays. T was measured using LC-MS/MS, free fractions and body mass index (BMI) were calculated. Linear mixed effects modelling was used for longitudinal analysis. Age at baseline and BMI were used as covariates.
Results: Men were 34.5 ± 5.5 years at baseline and 46.4 ± 5.8 years at follow up. During this period BMI increased from 25.1 kg/m² to 26.3 kg/m². At both time points, age and BMI negatively associated with total T and free T (all P < 0.001), and BMI also negatively associated with SHBG (P < 0.001).During follow up, total T levels decreased 14.4% (586.51 ng/dl vs 502.22 ng/dl at baseline and follow-up, respectively, after correction for age at baseline; P < 0.001). The decrease in total T was less pronounced after correction for BMI and changes therein with a decrease of 10.2% (P < 0.001). Free T decreased 17.9% (11.12 ng/dl vs 9.18 ng/dl after correction for age at baseline). The decrease in free T was less pronounced after correction for BMI and changes therein with a decrease of 16.1% (P < 0.001). After adjustment for age and BMI, SHBG increased 5.9% (37.8 nmol/l vs 40.15 nmol/l) , LH increased 6.8% (4.465 U/l vs 4.791 U/l) and FSH increased 15.5% (4.340 U/l vs 5.139 U/l) (allP < 0.001) during follow-up. Further, older age at baseline was associated with larger changes in SHBG (r = 0.115; P = 0.002) and FSH (r = 0.08; P = 0.032).
Conclusion: Already from the 4th decade of life, healthy men experience decreases in total and free T levels, independently from changes in BMI. Given the concurrent rise in gonadotropin levels, the decline in T in our population mostly likely arises from primary testicular dysfunction. Changes in T levels were independent from baseline age, suggesting a similar linear decrease across age within our population.