ECE2020 Audio ePoster Presentations Pituitary and Neuroendocrinology (217 abstracts)
Evaluation of early predictors of metabolic syndrome in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NET)
Filomena Bottiglieri 1 , Roberta Modica 1 , Luigi Barrea 1 , Federica de Cicco 1 , Roberto Minotta 1 , Giovanna Muscogiuri 1 , Silvia Savastano 1 , Antongiulio Faggiano 2 & Annamaria Colao 1
1Endocrinology Unit, Department of Clinical Medicine and Surgery, ‘Federico II’ University, Naples, Italy; 2Endocrinology Unit, Department of Experimental Medicine, Sapienza University, Rome, Italy
Metabolic syndrome and obesity (MetS) are supposed to have a role in cancer but data analysing their association with GEP-NET are lacking. Aim of this study was to explore the association of early predictors of MetS with GEP-NET, usingas tools Fatty Liver Index (FLI), a predictor of non-alcoholic fatty liver disease (NAFLD)and Visceral Adiposity Index (VAI), a gender-specific indicator of adipose dysfunction. A cross-sectional case-control observational study was conducted. VAI and FLI were calculatedin GEP-NET patientsreferred to the ENETS Center of Excellence of Naples, Endocrinology Unity of Federico II University between January 2015 and November 2019, as well as control healthy subjects, age, sex and BMI-matched. VAI isbased on waist circumference (WC), body mass index (BMI), triglycerides, and HDL cholesterol levels. FLI isbased on BMI, WC, triglycerides and GGT. We enrolled 103 patients with histologically confirmed G1/G2 GEP-NET (53 M, 50 F; 57.06 ± 15.95 years). GEP-NET were G1 (60%), G2 (40%) and metastatic in 26%. Differences in VAI and FLI were observed in GEP-NET patients compared with 103 controls. GEP-NET had a higher value of VAI and FLI compared with controls(P < 0.001). These differences were associated to GEP-NET aggressiveness. Both VAI and FLI were higher in G2 than in G1 (P < 0.007, P < 0.002 respectively), and in metastatic vs non metastatic (P < 0.001, P < 0.005 respectively). In addition, higher value of VAI and FLI were significantly correlated with progressive disease (P < 0.001). This is the first study reporting an association between early predictors of MetS, VAI and FLI, and GEP-NET. VAI and FLI may represent a tool of evaluation in all conditions in which overt MetS is not present in GEP-NET.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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