Endocrine Abstracts

Introduction: The SAGIT instrument was developed for clinicians to assess the status and evolution of the disease in patients with acromegaly. Currently, it is investigated in the validation phase. The aim of our study was to evaluate the potential utility of SAGIT instrument for distinguishing acromegaly clinical stages and its usefulness in treatment decision-making at a single Polish endocrine center.

Patients and Methods: Medical charts of adults with confirmed acromegaly hospitalized at the Department of Endocrinology within the last 24 months were retrospectively reviewed. Clinical and biochemical data were collected. SAGIT instrument was completed using patients’ medical records. Patients were divided into three categories: stable/controlled; active/uncontrolled; treatment-naïve. Also, treatment decisions were recorded as: continue current therapy with no change/no treatment initiation; intensify current therapy/initiate a treatment; reduce the current treatment.

Results: Among 108 patients, 58% were female, the average age was 55.5 years, and the median time of disease duration was 90 months. Median BMI was 28.5 kg/m². There were 14 treatment-naïve patients. Fifty % (n = 47) of treated patients did not achieve biochemical control. Current acromegaly treatment was continued in 38.3% (n = 18) of these patients. Median SAGIT score in treatment-naïve patients was higher than in treated patients (13 vs 6; P = 0.004). Also, patients who did not exhibit hormonal control had a higher SAGIT score than the controlled group (11 vs 4, P < 0.001). In ROC curve analysis, SAGIT score of 6 or less discriminated controlled patients from uncontrolled (P < 0.0001, sensitivity 85.1%, specificity 77.0%). Lack of signs and symptoms (S = 0) predicted controlled disease with a sensitivity of 83% and specificity of 39.3% (P = 0.0114). In uncontrolled treated patients, SAGIT score higher than seven indicated for treatment change (P = 0.0009, sensitivity 79.3%, specificity 66.7%)

Conclusions: The SAGIT instrument is easy to use even when completed in the retrospective medical-record review. Our study indicates for its potential utility for distinguishing clinical stages of acromegaly and in decision-making.