Endocrine Abstracts

Clinicians recognize patients persistently experience residual symptoms of thyrotoxicosis or hypothyroidism etc. despite having achieved circulating levels of TSH and FT4 within the conventional normal ranges. In fact, many pathological conditions affect preferred TSH and FT4. In addition, evidences indicate that the laboratory-quoted normal thyroid hormones as well as TSH reference range could not be always appropriate for everyone in clinical practice. In neonates, infants, children, adolescents and elderly serum concentrations of the thyroid hormones show a clear age and sex dependency. Age- and sex-specific normal reference intervals are an important prerequisite for interpreting thyroid hormone measurement. A comprehensive literature search was performed on PubMed, UPTODATE, NCBI over publications within the last 3 decades. A total number of 43 references were retrieved based on search terms including thyroid hormone reference intervals, age; sex; and related TSH intervals, thyroid disorders and optimal TSH range. We extracted data about concentration of thyroid hormones in various pathological conditions. We extracted thyroid hormones data in various physiological conditions e.g. pregnancy, menopause etc. This data was inserted in a MS Excel file and subsequently implemented into MATLAB software as a matrix. A GUI was then developed based collected data matrix to calculate individualized thyroid hormone set points based on patient input parameters comprise age, sex and several routine pathological conditions e.g. hypothyroidism, total thyroidectomy. Both euthyroid set points of patients with primary hypothyroidism, total thyroidectomy, and lobectomy etc., can be straightforwardly derived from hormone calculator App using personal indications of each patient. It can be shown that every individual has a preferred personalized set point. This software provide the preferred set points to be rationally computed using our proposed algorithm implementable for computer-aided calculations. This could facilitate precise targeted dosing of patients in personalized medicine. The proposed GUI could provide intra-individual physiological optimal ranges compared to laboratory-quoted normal ranges and assist physicians making proper decisions.