ECE2020 Audio ePoster Presentations Diabetes, Obesity, Metabolism and Nutrition (285 abstracts)
Anemia is associated risk factor of chronic kidney disease in diabetes type 2 patients
Volha Vasilkova 1 , Tatsiana Mokhort 2 , Ludmila Korotaeva 3 , Oksana Shestovets 3 , Yulia Yarets 3 , Yana Borovets 1 & Irina Vasuhina 3
1Gomel State Medical University, Endocrinology, Gomel, Belarus; 2Belarusian State Medical University, Endocrinology, Minsk, Belarus; 3The Republican Research Centre for Radiation Medicine and Human Ecology, Laboratory, Gomel, Belarus
Introduction: Diabetes is the leading cause of chronic kidney disease (CKD) and is associated with excessive cardiovascular morbidity and mortality. On the other hand, anemia is common among those with diabetes and CKD and greatly contributes to patient outcomes.
Aim: The aim of this study was to investigate the prevalence and associated risk factors of CKD among the patients with diabetes type 2 (DT2).
Methods: We examined at baseline 300 patients with DT2 and CKD aged between 30 and 65 years. Control group included 100 patients without diabetes the same age. Blood samples for measurement of routine chemistry were taken after an overnight fast of at least 12 hours. The albumin and creatinine levels were measured for albuminuria and estimated glomerular filtration rate (eGFR) assessment. Anemia was defined as hemoglobin level <13 g/dl in men and <12 g/dl in women. Univariate and multivariate logistic regression analyses were conducted to identify factors associated with CKD.
Results: The total prevalence of anemia was higher in patients with DT2 in comparison to control (57.3% vs 28.6%, P = 0.003). Prevalence was higher in diabetics with decreasing eGFR (P for trend 0.001). In multivariate analyses, anemia (OR = 8.167, 95% CI : 3.785–35.145), hyperuricemia (OR = 0.956, 95% CI : 0.918–0.975) and hyperhomocysteinemia (R = 1.856, 95% CI : 1.718–1.975) were independently associated with the presence of CKD.
Conclusion: Prevalence of anemia progressively increases with advancing stages of CKD and is higher in patients with DT2 than matched non-diabetic patients. Thus, common chronic non-communicable diseases, including diabetes, anemia, hyperhomocysteinemia, hyperuricemia were associated with greater prevalence of CKD.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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