Endocrine Abstracts

The study involved 37 people with type 2 diabetes who received oral hypoglycemic medications, aged 35–65 years. The first group included 22 people with a daily work schedule, and the second group included 15 people with a night work schedule of more than 5 years as a model of patients with impaired circadian rhythm. Comparative analysis of descriptive data shows the predominance of creatinine levels (P < 0.05) and, accordingly, a decrease in GFR (P 0.05) in the group of patients with night mode. Despite poor glycemic control, long duration of DM2, AH, and greater age in the group of patients working during the day (P < 0.05), GFR values in both groups do not differ statistically, which indicates a decrease in the filtration capacity of the kidneys in both groups. The earlier decrease in the filtration capacity of the kidneys in group 2 can be explained by a higher level of glycemic variability, the value of which has a direct correlation with the level of creatinine (r = 0.656; P < 0.05) and the reverse – with GFR (r = −0.657; P < 0.05). Despite the significant difference between patients ‘age, diabetes experience, and carbohydrate metabolism, there was no statistically significant difference between TSS and NIS-LL in the groups. Correlation analysis showed that the severity of diabetic polyneuropathy in group 1 patients was negatively affected by weight gain, AH experience (TSS scores positively correlated with BMI (r = 0.564; P < 0.05) and AH experience (r = 0.472; P < 0.05)) and SD2 experience (NIS-LL has a positive correlation with SD2 experience (r = 0.459; P < 0.05) and AH experience (r = 0.312; P < 0.05)), and an increase in HDL leads to an improvement in the course of diabetic polyneuropathy. indicators of polyneuropathy (TSS and NIS-ll) are negatively correlated with the level of HDL (R = −0.4; P < 0.05).Similar data were obtained in other studies. In group 2 patients, the severity of diabetic polyneuropathy, according to TSS scales, is negatively affected by an increase in LDL (r = 0.550; P < 0.05), cholesterol (r = 0.516; P < 0.05), and glycemic variability (r = 0.330; P < 0.05). The manifestation of diabetic polyneuropathy in group 2 of the same degree as in group 1 patients can be explained by the higher variability of glycemia in patients with night mode.