Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2020) 70 AEP497 | DOI: 10.1530/endoabs.70.AEP497

ECE2020 Audio ePoster Presentations Diabetes, Obesity, Metabolism and Nutrition (285 abstracts)

The effectiveness of complex treatment of obesity on theknee osteoarthritisand the dynamics of cytokines, depending on the degree of weight loss

Ekaterina Strebkova & Ludmila Alekseeva


Nasonova Research Institute of Rheumatology


Objective: Assess the effectiveness of complex treatment of obesity with the use of orlistat (intestinal lipase inhibitor) on the knee OA (KOA) and the dynamics of cytokines (CRP, IL-6, TNF-α) depending on the degree of weight loss.

Methods: 50 female patients (45–65 y.o.) with Kellgren-Lawrence stage II-III KOA and obesity (BMI > 30 kg/m²). Patients in Group 1 (n = 25) took 120 mg of orlistat 3 times a day in combination with a low-calorie diet and exercise for 6 months. Patients in Group 2 (n = 25) were recommended non-drug therapy for obesity for 6 months. At baseline and after 6 months, the clinical parameters of the KOA (WOMAC) were evaluated, the quality of life was assessed (EQ-5D). A laboratory study of peripheral blood was conducted at baseline and after 6 months: CRP, IL-6, TNF-α.

Results: After 6 months of complex treatment of obesity with the use of orlistat, patients in Group 1 achieved a significant weight loss of 10.07% (P < 0.05). Depending on the degree of weight loss in Group 1, 15 patients lost > 10% and 10 patients lost 5–9.9% of the initial body weight. In the 2nd group, an insignificant weight loss of 0.84% (P > 0.05) was achieved, all patients in Group 2 lost less than 5%. Depending on the degree of weight loss, it is noted that in patients with weight loss more than 5% better than WOMAC (pain, stiffness, functional state) (P < 0.05), EQ-5D (P < 0.05) compared with less weight loss. In patients with weight loss > 10%, a significant decrease in CRP level was observed (P = 0.03) compared with baseline and patients with a 5–9.9% weight loss (P = 0.03) and < 5% (P = 0.02). Data for statistically significant changes from TNF-α and IL-6, depending on the degree of weight loss was not detected.

Conclusion: The results of the study demonstrated a significant effectiveness of the complex treatment of obesity in patients with KOA. A decrease in body mass of more than 5% helps to improve the clinical manifestations of KOA. A decrease in body weight of more than 10% demonstrates a decrease in the level of CRP, which suggests an effect on meta-inflammation in OA.

Volume 70

22nd European Congress of Endocrinology

Online
05 Sep 2020 - 09 Sep 2020

European Society of Endocrinology 

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