Endocrine Abstracts

Background: People with type 2 Diabetes Mellitus (DM2) more predisposed to Non-Alcoholic Fatty Liver Disease (NAFLD). Accompanied chronic pancreatitis impaired glycemic control by affecting gastrointestinal absorption, also by affecting of pancreatic insulin secretion. We study the frequency of NAFLD in DM2 patients with accompanied chronic pancreatitis.

Material and Methods: In 44 people with DM2 blood glucose, HbA1c, Cholesterol, triglycerides, LDLP, HDLP, fibrinogen, ALAT, ACAT, bilirubin levels, prothrombin index, serum alpha amylase activity were measured. In addition pancreas, liver structure assessed by ultrasound. Results showed that 37% observed people with DM2 have NAFLD. Blood glycemia, HbA1c, fibrinogen, ALAT, ASAT, bilirubin levels were comparable in both with NAFLD and without. Blood Cholesterol, Triglycerides, VLDLP levels were significantly higher in patients with NAFLD which confirmed by ultrasound. Interestingly, that 26 (59%) patients with DM2 have accompanied chronic pancreatitis, which determined in 15 patients (94%) in the group with NAFLD and in 11 patients (39%) without NAFLD, which suggested about involvement of chronic pancreatitis into pathogenesis of NAFLD.

Conclusion: NAFLD is a frequent among people with DM2 and determined in 37%. Interestingly, NAFLD showed the relationship with presence of chronic pancreatitis in people with DM2. Chronic pancreatitis in patients with DM2 involved into pathogenesis of NAFLD.