Endocrine Abstracts

Objective: To establish the association of triglyceride-glucose index (TyG) index with metabolic parameters of cardiovascular risk (CVR) in patients with arterial hypertension (AH). We examined 255 patients – 123 women and 132 men aged 45–55 years with AH stage II grade 2which were divided on TyG index into two groups: gr.1 –TyG index < 4.81 units (n = 134) and TyG index > 4.82 units (n = 121) – gr.2.

Methods: HOMA-insulin resistance (IR), biochemical blood analysis (lipid metabolism parameters, uric acid (UA)).

Results: Analysis of metabolic differences in patients with AH depending on IR presence for TyG index shows that in the case of decreased tissue sensitivity to insulin, the state of lipid metabolism is deteriorated mainly due to disturbances in the system oflipolisis and lipids containing TG, lipid transport system as evidenced by an increase in TG levels of 2.26 times (P < 0.0001) and magnitude of the lipid ratio of TG/HDL 2.88 times (P < 0.0001). The retention of TC in peripheral tissues in IR (TyG index > 4.82 units) is accompanied by HDL lowering by 16.7% (P < 0.0001) and an increase in the lipid ratio of TC/HDL by 33, 7% (P < 0.0001). Poor efficiency of the reverse transport of TC system functioning in IR condition is also confirmed by the lipid ratio increase of LDL/HDL by 26.3% (P < 0.0008), which indicates the advantage of the TC flow to the peripheral tissues over his withdrawal. The lipid profile in IR differs by an additional 24.8% (P < 0.0001) increase of non-HDL-C compared to individuals without IR. In relation to TC (non-HDL/TC), this increase is 18.2% (P = 0.02). The average of UA did not exceed normal ranges (0.360 mmol/l) in groups compared to TyG index, but was 10.7% (P = 0.005) higher at TyG index > 4.82 units.

Conclusions: Association of TyG index in patients with AH with atherogenic dyslipidemia as a CVR factor, is realized due to the lipoprotein lipolysis of TG-containing lipoproteins system and inverse TC transport system disorders. The association of TyG index with hyperglycemia and UA levels disoders is realized through metabolic factors as glucose tolerance disturbance and hyperuricemia.