ECE2020 Audio ePoster Presentations Diabetes, Obesity, Metabolism and Nutrition (285 abstracts)
The effect of SNP (rs174537) in FADS1 gene on fatty acid composition in serum lipids
Tereza Metelcová 1,2 , Markéta Vaňková 2 , Hana Zamrazilová 2 , Milena Hovhannisyan 2 , Eva Tvrzická 3 , Barbora Staňková 3 , Martin Hill 2 , Josef Včelák 2 & Marie Kunešová 2,3
11st Medical Faculty, Charles University, Prague, the Czech Republic; 2Institute of Endocrinology, Prague, Czech Republic; 34th Department of Internal Medicine, 1st Medical Faculty, Charles University, Prague, Czech Republic
Background: Fatty acid desaturase 1 (FADS1) gene controls the fatty acid metabolism pathway in the human body (Sergeant et al., 2012). Single nucleotide polymorphism (SNP) in FADS1 gene and percentage of polyunsaturated fatty acids inserum lipids was associated (Klingel et al., 2018). Genetically predisposition to higher plasma arachidonic and stearic acid levels were associated with incidence oflarge-artery stroke and venous thromboembolism (Yuan et al., 2019).
Methods: Samples obtained in the COPAT project (Childhood Obesity Prevalence And Treatment) were used. Genomic DNA was extracted from peripheral blood leucocytes in whole blood samples. For genotype analysis TaqPath (LC480, Roche) was used. Sample of 754 adolescents (376 girls and 378 boys) from the Czech Republic was examinated in this project. Association of SNPs with fatty acid composition was conducted using the SIMCA-P12 (Umetrics, Umea, Sweden).
Results: The relationship of the risk allele (rs174537) with 12 fatty acids was significant. In SNP (rs 174537) has been relationship between risk allele and two fatty acids (20:4 n-6; 18:3 n-6) in all three lipid classes.
Conclusion: Single nucleotide polymorphisms (rs174537) in FADS1 gene had a significant negative relationship with two fatty acids, (20:4 n-6 and 18:3 n-6), in all three lipid classes.
Conflict of Interest: None Disclosed.
Funding: Supported by grants: MZ ČR – RVO EÚ 00023761, AZV MZ ČR 17-31670.
References
1. Klingel SL, Valsesia A, Astrup A, Kunesova M, Saris WH, Langin D, Viguerie N & Mutch DM. FADS1 genotype is distinguished by human subcutaneous adiposetissue fatty acids, but not inflammatory gene expression. International Journal of Obesity, 2018 1.
2. Sergeant S, Hugenschmidt CE, Rudock ME, Ziegler JT, Ivester P & Ainsworth HC, et al. Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome. Br J Nutr. 2012 107 547–555.
3. Yuan S, Bäck M, Bruzelius M, Mason AM, Burgess S & Larsson S. Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases: A Mendelian Randomisation Study. Nutrients, 2019; 11(12) 3001.
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Endocrine Abstracts
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