Endocrine Abstracts

Introduction: The prevalence of diabetes increases during cirrhosis resulting from a significant alteration in carbohydrate metabolism modifying the management of diabetes and worsening the liver prognosis. The aim of this work is to determine the prevalence of diabetes during cirrhosis, and to assess its prognostic impact on the disease.

Material and method: this is a study collecting all cirrhotics followed in the gastroenterology department over a period of 4 years. We divided the patients into 2 groups: G1: diabetic patients and G2: non-diabetic patients.

Results: A total of 71 patients with a mean age of 62 years (25–83 years), were collected. Viral origin was the most common cause (40.8%). The prevalence of diabetes was estimated at 45.07% (n = 32). The factors associated with diabetes were: advanced age (age> 60, P = 0.04), presence of another criterion of metabolic syndrome (P = 0.001), viral etiology C (P = 0.045) and a disease classified Child–Pugh B (P = 0.04). Stage C was more frequent in group 1 patients with no significant difference (31.25% vs 28.2%, P = 0.4). There was no significant difference between the 2 groups regarding gender. In addition, there was no difference between the 2 groups concerning the risk of occurrence of complications of cirrhosis (oedemato-ascitic decompensation, refractory ascites, digestive hemorrhage due to varicose vein rupture, ascites fluid infection and hepatic encephalopathy) apart from hepatocellular carcinoma which was more frequent in group 1 without significant difference (29.03% vs 15.38%, P = 0.1).

Conclusion: The prevalence of diabetes during cirrhosis is quite high. This requires special attention for therapeutic management and constitutes a negative prognostic factor aggravating the state of the liver.