Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2020) 70 AEP298 | DOI: 10.1530/endoabs.70.AEP298

ECE2020 Audio ePoster Presentations Diabetes, Obesity, Metabolism and Nutrition (285 abstracts)

High prevalence of cognitive dysfunction and vitamin B12 deficiency in patients with type 2 diabetes over 50 years

Letícia Weinert 1,2 , Fabiana Romani 3 & Eduardo Coelho Machado 3


1Hospital Escola UFPEL, Endocrinology, Pelotas, Brazil; 2Catholic University of Pelotas, Campus I, Pelotas, Brazil; 3Universidade Federal Pelotas Faculdade de Medicina, Pelotas, Brazil


Introduction: Hyperglycemia is a common disorder in elderly patients. Diabetes management in this population requires evaluation of medical, pharmacological and functional domains. Screening for diabetes chronic complications should include, in addition to traditional micro- and macrovascular disease, search for cognitive impairment and vitamin B12 deficiency.

Objective: To evaluate the prevalence of cognitive impairment, depression, and associated clinical variables in a population of adult patients with type 2 diabetes.

Methods: Individuals over 50 years and with type 2 diabetes, assisted at the Federal University of Pelotas, South of Brazil, were included in the study. We performed a cross-sectional study with application of a face-to-face questionnaire and evaluation of outpatient clinical records for clinical and demographic variables analysis. We use Mini-Mental State Examination (MMSE) to assess cognitive impairment, and Patient Health Questionnaire-2 (PHQ) and PHQ-9 to evaluate depression.

Results: We included 116 patients, with a median age of 62 years, 68.1% were women, 76.7% have white skin color, and 81% have 8 years of study or less. The mean A1c was 9.6%. Over 70% of the patients have at least one microvascular complication, and 52.6% have clinical macrovascular disease. The prevalence of cognitive dysfunction was 35.3% and that of depression was 33.6%. The group of patients with cognitive dysfunction has higher rates of B12 deficiency (60% vs 36.6% in controls; P = 0.01) and of benzodiazepine use (51.3% vs 30.6% in controls; P = 0.03). The presence of microvascular complications was also higher in the group of patients with cognitive dysfunction (85.4% vs 66.7% in controls, P = 0.003). Other clinical variables were not different between groups. B12 deficiency was associated with cognitive impairment even after adjustments [1.78 (1.07–2.98)]; while the association with benzodiazepine use was not significant after statistical adjustments [1.58 (0.95–2.64)].

Discussion: Patients over 50 years and with type 2 diabetes have a high prevalence of cognitive dysfunction and depression, and B12 deficiency was associated with cognitive impairment. Therefore, we strongly suggest that clinical doctors actively search for these comorbidities.

Volume 70

22nd European Congress of Endocrinology

Online
05 Sep 2020 - 09 Sep 2020

European Society of Endocrinology 

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