ECE2020 Audio ePoster Presentations Diabetes, Obesity, Metabolism and Nutrition (285 abstracts)
Pulse wave velocity and circulating Retinol binding protein 4: A cross sectional association in early postmenopausal women
Eleni Armeni 1 , Meletios P Nigdelis 2 , Asimina Chondrou 1 , Panagiotis Anagnostis 2 , Areti Augoulea 1 , Dimitrios Rizos 3 , George Kaparos 3 , Andreas Alexandrou 1 , Dimitrios G Goulis 2 , Raphael Patras 4 , Evmorfia Aivalioti 4 , Kimon Stamatelopoulos 4 & Irene Lambrinoudaki 1
1National and Kapodistrian University of Athens, Aretaieio Hospital, 2nd Department of Obstetrics and Gynecology, Athens, Greece; 2Medical School, Aristotle University of Thessaloniki, Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Thessaloniki, Greece; 3National and Kapodistrian University of Athens, Aretaieio Hospital, Hormonal and Biochemical Laboratory, Athens, Greece; 4National and Kapodistrian University of Athens, Alexandra Hospital, Department of Therapeutics and vascular pathophysiology, Athens, Greece
Introduction: Recent evidence recognized the value of Retinol-Binding Protein (RBP4), as potential biomarker of cardiovascular and cerebrovascular pathology. The possible association between RBP4 and functional vascular disease remains unexplored, while recent data in postmenopausal populations suggested lack of association between RBP4 and subclinical atherosclerosis. We evaluated the possible link between RBP4 and menopause-specific cardiovascular risk factors, in a sample of apparently healthy postmenopausal women.
Methods: We recruited 123 healthy postmenopausal women, retrieved from a University Menopause Clinic. Inclusion criteria were menopausal age of equal or less than 10 years. Exclusion criteria were: 1) no intake of hormone therapy, antihypertensive, Participating women were not on treatment with hormone therapy, antihypertensives or hypolipidemic treatment. Women were instructed to fast for at least 8 hours and not to smoke, aiming for a blood tests for biochemical/hormonal assessment. Sonographical evaluation was performed immediately thereafter and included carotid-femoral pulse wave velocity (PWV) and calculation of the carotid artery stiffness index (S.I.)
Results: Univariate correlations were observed between RBP4 values and age, LDL-cholesterol and marginally significant with S.I., PWV, homocysteine, circulating estrogen, triglycerides. Women with RBP4 values higher than the median vs lower RBP4 values presented with higher levels of homocysteine (homocysteine: RBP4 < 10.5 ng/ml vs ≥ 10.5 ng/ml: 11.2 ± 2.81 µmol/l vs 12.52 ± 3.44 µmol/l, P-value = 0.049 ANCOVA adjusted for age, BMI, HOMA-IR). PWV was independently associated with RBP4 (b-coefficient = 0.440, P-value = 0.007), in multivariate models adjusted for age, menopausal age, LDL-cholesterol, circulating estrogen, smoking, pulse pressure, homocysteine, Similarly, S.I. was associated with RBP4 levels (b-coefficient = 0.324, P-value = 0.039) and insulin resistance, in models adjusted forage, menopausal age, LDL-cholesterol, circulating estrogen, smoking.
Conclusions: The results of this study show that higher RBP4 serumlevels are associatedwith greater aortic and carotid stiffness, in a sample of healthy postmenopausal women. Larger studies are required to further elucidate the significance of our findings.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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