ECE2020 Audio ePoster Presentations Bone and Calcium (121 abstracts)
Successful quantification of symptom load by a disease-specific questionnaire HPQ 40/28 and analysis of influencing biochemical parameters in patients with postsurgical hypoparathyroidism
Deborah Wilde 1 , Lara Wilken 1 , Bettina Stamm 2 , Christina Heppner 3 , Andreas Leha 4 , Martina Blaschke 1,3 , Christoph Herrmann-Lingen 5 & Heide Siggelkow 1,3
1University Medical Center Goettingen, Clinic for Gastroenterology and Endocrinolgy, Goettingen, Germany; 2MVZ Endokrinologikum Saarbrücken, Saarbruecken, Germany; 3MVZ Endokrinologikum Goettingen, Goettingen, Germany; 4University Medical Center Goettingen, Institute for Medical Statistics, Goettingen, Germany; 5University Medical Center Goettingen, Department for Psychosomatic Medicine and Psychotherapy, Goettingen, Germany
In hypoparathyroidism (HypoPT), patients suffer severely from reduced quality of life. The complexity of HypoPT demands a disease-specific control instrument to characterize symptom load. We employed a newly developed disease-specifichypoparathyroid patient questionnaire (the HPQ 40/28) to investigate and quantify HypoPT patients’ complaints and contributing factors. In this cross-sectional, two-center study, patients with postsurgical HypoPT (n = 49) were matched for sex and age and compared to patients having undergone thyroid surgery without HypoPT (ThySu, n = 39)) and patients with primary hyperparathyroidism (pHPT, n = 35). The HPQ 40/28 was filled in when patients visited the respective center. Clinical background information, blood tests,as well as current medication were documented by the physician. Serumcalcium laywithin the reference range in 87% of HypoPT patients, serumphosphate in 95.7%, and calcium-phosphateproduct in 100%. HPQ 40/28 scores for the scales “pain and cramps” (PaC), “neurovegetative symptoms” (NVS), “numbness or tingling”, and “heart palpitations” were significantly elevated in comparison with control groups. Correlations between complaints and laboratory parameters could be demonstrated in the HypoPT group, with serumcalcium correlating with NVS (r = 0.309, P < 0.05) and serumphosphate with loss of vitality (r = 0.349, P < 0.05). Calcium-phosphate product was the main contributor to symptom load with an influence on PaC (r = 0.295, P < 0.05), loss of vitality (r = 0.498, P < 0.001), numbness or tingling (r = 0.328, P < 0.05), and memory problems (r = 0.296, P < 0.05). In conclusion, the newly developed HPQ 40/28 successfully identified and quantified symptoms typical in HypoPT patients. Using the HPQ 40/28, the calcium-phosphateproduct was identified as the predominant factor in the severity of complaints in HypoPT
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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