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Endocrine Abstracts (2019) 68 P9 | DOI: 10.1530/endoabs.68.P9

Kings College London, London, UK


Introduction: Gastric NENs are increasingly being diagnosed at endoscopy. The majority of these are type 1 gastric NEN. However, around 10–20% can be type 3 or type 4 Gastric NENs.

Methods: A retrospective review performed of 54 patients with gastric NENs referred to a tertiary centre during 2014 to 2019.

Results: Of the 54 cases referred, 45 were type 1 gastric NENs and the 9 were type 3 Gastric NENs. Of the 45 type 1 gastric NENs: 2 patients had locally advanced/metastatic disease at diagnosis, the other 43 had localised disease. Of the 9 patients with type 3 gastric NETs 4 were grade 1 WDNET with Ki67 <2%; 2 cases were grade 2 well differentiated NETs and 1 grade 3 WDNEC and 2 poorly differentiated NEC grade 3. Over the follow up period none of the 45 type 1 gastric NETS developed gastric adenocarcinoma. 5 patients required endoscopic resection of lesions > 1 cm during the period of follow up. There were no perforations or complications post EMR or ESD of these lesions. 2 patients underwent sub-total gastrectomy, lymphadenectomy for locally advanced type 1 gastric NENs, 1 patient had liver metastases resected as well. Of the type 3 gastric NENs, 4/9 patients underwent curative surgical resections and 1 underwent palliative surgical resections. 2 endoscopic resections and 2 underwent palliative chemotherapy.

 Average AgeAverage Length of diagnosis TypeDistant MetsManagementMortality
G3 I and II513.6 years4 G3 type 102 EMR 2 wedge resection4 alive disease free
G3 and advanced672.6 years2 G2 NET, 1 G3 NET and 2 NEC32 curative surgery, 1 palliative surgery, 1 palliative chemo and 1 no treatment1 died from the disease, 2 have active disease, 2 alive disease free

Conclusion: The majority of gastric NENs are type 1. Around 10% of patients require endoscopic resection at some point during surveillance. The histological characteristics of type 3 gastric NENs are diverse and the well differentiated low grade tumours can be managed with endoscopic or limited surgical resection.

Volume 68

17th Annual Meeting of the UK and Ireland Neuroendocrine Tumour Society 2019

Birmingham, UK
02 Dec 2019 - 02 Dec 2019

UK and Ireland Neuroendocrine Tumour Society 

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