Endocrine Abstracts

Objective: Diabetes mellitus is the global epidemic of the 21st century, and it leads to the development of microvascular and macrovascular complications. Elevated blood glucose level in T2DM causes disturbances of blood cells and its parameters. The aim of the research is to determine changes in the complete blood count (CBC) depending on glycemic control, the disease duration and their association with degenerative complications.

Methods: The study was prospective from 2016 to 2017. It included a total of 137 subjects, 90 with T2DM and 47 healthy. The subjects were divided into several ways, with and without T2DM, with HbA1c≤7% and with HbA1c>7%, and groups with and without complications. We analyzed CBC parameters, parameters of glycoregulation, lipid status and performed anthropometric measurements.

Results: There were statistical difference between group with T2DM and healthy subjects for WBC, eosinophils, Hgb, MCH, MCHC, ESR in 2016, and neutrophils, monocytes, RDW, PDW, ESR in 2017. In the group of T2DM patients with duration of disease longer than 6 years we found elevated value of MCHC, PDW. In relationship to glycoregulation, significant differences in PMDW, large platelets and RDW were found in the group HbA1c>7%. According to degenerative complications significant differences were revealed in lymphocytes, neutrophils in the group with microvascular complication, and PDW in the group with macrovascular complications.

Conclusion: Based on the results of our research, it can be concluded that there is an association between particular hematological parameters and glycoregulation, diabetes mellitus, as well as relationship with degenerative complications in patients with T2DM.