EYES2019 7th ESE Young Endocrinologists and Scientists (EYES) Meeting Oral Presentations (67 abstracts)
Arterial stiffness is an independent predictor for risk of mortality in patients with type 2 diabetes mellitus: the REBOUND study
Jeong Mi Kim 1, , Sang Soo Kim 1, , In Joo Kim 1, , Mi Kyung Kim 3 , Soon Hee Lee 4 , Chang Won Lee 5 , Min Chul Kim 6 & Jun Hyeob Ahn & and for the Relationship between Cardiovascular disease and Brachial-ankle Pulse Wave Velocity (baPWV) in Patients with Type 2 Diabetes (REBOUND) Study Group 7
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea; 2Biomedical Research Institute and Department of Internal Medicine, Pusan National University Hospital, Busan, Korea; 3Department of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea; 4Department of Internal Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea; 5Department of Internal Medicine, Busan St. Mary’s Hospital, Catholic University of Pusan, Busan, Korea; 6Department of Internal Medicine, Ilsin Christian Hospital, Busan, Republic of Korea; 7Department of Internal Medicine, Good Moonhwa Hospital, Busan, Korea. *These authors have contributed equally to this work reported, thus both should be considered as the corresponding-authors.
Objective: Brachial-ankle pulse wave velocity (baPWV) was used as a noninvasive marker of arterial stiffness. The aim of this study was to assess the association between arterial stiffness and cause specific mortality in patients with type 2 diabetes mellitus (T2DM).
Methods: This multicenter prospective observational study analyzed 2,320 patients with T2DM. The patients were divided into two groups according to baPWV (cutoff baPWV of 1,750 cm/s). Causes of death were obtained from death certificates, and cause-specific mortality rates were compared with four groups according to their baPWV. Cox regression models were used to estimate hazard ratios (HRs).
Results: There were 205 deaths (8.8%) in the study population during the 8.6 years of study. A univariate analysis revealed that the high-baPWV group predicted a greater risk of all-cause mortality (HR =4.41, P <0.001), cancer mortality (HR =3.85, P < 0.001), and cardiovascular mortality (HR =3.33, P < 0.001) than the low-baPWV group. A multivariate analysis adjusted for clinical variables including age and sex showed that the high-baPWV group remained predicted a greater risk of all-cause mortality (HR =2.57, P < 0.001), cancer mortality (HR =2.19, P=0.010), and cardiovascular mortality (HR =1.74, P=0.061) than the low-baPWV group.
Conclusions: The high-baPWV group predicted the risk of mortality in T2DM, supporting the prognostic utility of baPWV.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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