EYES2019 7th ESE Young Endocrinologists and Scientists (EYES) Meeting Oral Presentations (67 abstracts)
The influence of sex on the evolution of mesenteric metastasis in small intestinal neuroendocrine tumours
Anela Blažević 1 , Wouter Zandee 1 , Johannes Hofland 1 , Anand Iyer 1 , Gaston JH Franssen 2 , Marie-Louise F van Velthuysen 3 , Tessa Brabander 4 , Richard A Feelders 1 , Leo J Hofland 1 & Wouter W de Herder 1
1Department of Internal Medicine, Section Endocrinology, Rotterdam, the Netherlands; 2Department of Surgery, Rotterdam, the Netherlands; 3Department of Pathology, Rotterdam, the Netherlands; 4Department of Radiology and Nuclear Medicine, ENETS Centre of Excellence, Erasmus University Medical Center and Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Objective: A mesenteric mass with surrounding mesenteric fibrosis (MF) is a hallmark of small intestinal neuroendocrine tumours (SI-NETs) and known to induce abdominal complications. However, little is known on the evolution over time and the pathways involved in progression. Our aim was to assess the development of the metastatic mesenteric mass over time and find predictors for progression.
Methods: Retrospectively, 530 patients with proven SI-NET and ≥2 available CT-scans were included for analysis. The presence and growth of a mesenteric mass was assessed according to RECIST 1.1 on every CT-scan. Based on these results, expression of estrogen receptor alpha (ESR1) and androgen receptor (AR) were assessed by RT-qPCR.
Results: Mesenteric metastasis was present in 64.2% of the patients and males had a significant increased risk (OR 1.88, P=0.001). Growth was observed in 9.2% of the patients with a median time to growth of 39.4 months. Independent predictors of growth were having a mesenteric mass at baseline (OR 7.99, P=0.001) and male gender (OR 2.02, P=0.03). Analysis of 20 primary SI-NETs and paired normal intestine showed significantly increased ESR1 and AR expression in tumours and significantly increased ESR1 expression in tumours of patients with severe MF
Conclusion: We found that the SI-NET-associated mesenteric mass has an indolent growth pattern. Also, our results suggest that sex steroids might be involved in the pathobiology of mesenteric metastases as we found an increased risk for mesenteric mass growth in males and increased expression of ESR1 in patients with MF. Further research is ongoing to determine ESR1 and AR expression in the mesenteric mass and distribution within the tumour.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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