EYES2019 7th ESE Young Endocrinologists and Scientists (EYES) Meeting Oral Presentations (67 abstracts)
Effect of treatment with Cinacalcet on TBS and BMD in patients with chronic renal failure with secondary hyperparathyroidism in hemodialysis
Mola Reyes Laura 1 , Librizzi María Soledad 1 , Hernández Martínez Eduardo 2 , Mérida Herrero Eva 2 , Trujillo Cuéllar Hernando 2 , Martín Arriscado Cristina 3 & Hawkins Carranza Federico 1
1Endocrinology and Nutrition Department. Hospital 12 de Octubre, Madrid. Spain; 2Nephrology Department. Hospital 12 de Octubre, Madrid. Spain; 3Research Assistance Department. Hospital 12 de Octubre, Madrid. Spain.
Background: Fractures are frequent in patients with chronic renal failure (CRF) with secondary hyperparathyroidism (SHPT) undergoing hemodialysis. Cinacalcet (CT) is a drug used in the reduction of hypercalcemia in these patients that acts through the lintel calcium sensor in the parathyroid gland. Recently, it has been pointed out that CT can reduce fractures in these patients by unknown mechanisms (EVOLVE Trials 2015).
Objectives: To evaluate the effect of CT on Trabecular Bone Score (TBS) and Bone Mineral Density BMD in patients with CRF and SHPT.
Methods: Cross-sectional study with two groups: patient in treatment with CT and patients without treatment with CT (control group). Dimensional measurement by DXA Hologic 4500 QDR and TBS with MediMaps software.
Results: 14 patients with CT and 24 patients in the control group. Mean age was 56.2±11.6 vs. 62.5±14.9 (P=0.39) years, sex M/W 6/8 vs. 15/8. Body mass index (BMI): 22.6±2.5 vs. 23.6±3.5, P=0.33, in the group with CT and control respectively. TBS 1.234±0.106 vs. 1373±0.154, P=0.05; BMD (lumbar) 0,778±0.163 vs. 0.832±0.143 P=0.48; BMD (femoral neck) 0.640±0.090 vs. 0.709±0.16, p=0.15; BMD (total hip) 0.540±0.072 vs. 0.615±0.172, P=0.12; BMD (wrist) 0.507±0.078 vs. 0.617±0.151, P=0.01, respectively in the group with CT and control. T-score (lumbar): −2,566±1,373 vs. −1.723±1.666, P=0.26; T-score (femoral neck): −2.807±0.671 vs. −2.255±1.381, P=0.21; T-score (total hip): −2,500±0,749 vs. −1,895±1,361, P=0.02; T-score (wrist): −3.992±1.182 vs. −2.250±2.641 P=0.02.
Conclusions: TBS values in patients undergoing treatment with CT were lower than those in the control group, in the presence of similar BMD values in both groups. Further studies are needed to confirm that CT has positive effects on bone quality as measured by TBS.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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