EYES2019 7th ESE Young Endocrinologists and Scientists (EYES) Meeting Oral Presentations (67 abstracts)
Anthropometric and hormonal predictors of metabolic obesity phenotypes in menopause
Eleni Armeni 1 , Areti Augoulea 1 , Demetrios Rizos 2 , George Kaparos 2 , Anastasia Soureti 1 , Iliana Karagouni 1 , Michail Apostolakis 1 & Irene Lambrinoudaki 1
1Second Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Aretaieio Hospital, Athens, Greece; 2Hormonal and Biochemical Laboratory, National and Kapodistrian University of Athens, Aretaieio Hospital, Athens, Greece.
Objective: Aiming to identify individuals with more benign metabolic profile, we explored the link between anthropometric predictors as well as serum levels of sex hormones and phenotypes of metabolic health in non-obese postmenopausal women.
Methods: A total of 458 non-obese (BMI <30 kg/m2) postmenopausal women (age 55.2±7.1 years, BMI=24.6±2.8 kg/m2) were retrieved from the Menopause Clinic of Aretaieio Hospital, National and Kapodistrian University of Athens. The International Diabetes Federation diagnostic criteria for the definition of Metabolic Syndrome were used to classify women into metabolically obese (≥3 criteria, MONW) or metabolically healthy (<3 criteria, MHNW).
Results: Prevalence of phenotypes was as follows: MHNW 80.8% (370/458), MONW 19.2% (88/458). Compared to MHNW, MONW was associated with higher age and menopausal age, greater waist circumference & WHR, higher androgenicity (P-value<0.001, all cases); and lower levels of estrogen (P-value=0.047). Waist circumference was superior than WHR in predicting MONW (Waist≥ 86.5 cm, sensitivity 72.7%; specificity 69.4%). Waist circumference ≥ 86.5 cm predicted the MONW phenotype in a model adjusted for age and menopausal age (OR=4.689, 95% CI: 2.626 to 8.373, P-value<0.001). In models adjusted for age and menopausal age, MONW was predicted by: i) SHBG (OR=0.979, 95% CI: 0.967 to 0.990); ii) FAI (OR=1.339, 95% CI: 1.121 to 1.599, P-value=0.001). The association between FEI/E2 and the MONW phenotype was mediated by age.
Conclusion: Waist circumference greater than 86.5 cm or more pronounced androgenicity represent the most significant independent predictors of adverse metabolic health, irrespectively of age and menopausal age, in this sample of non-obese middle-aged women.
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Endocrine Abstracts
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