EYES2019 7th ESE Young Endocrinologists and Scientists (EYES) Meeting Poster Presentations (46 abstracts)
Rare case of hypopituitarism
Ilić Saša 1 , Draško Gostiljac 1 , Srđan Popović 1 , Sandra Đurđević Pekić 1 , Toplica Milojević 2 , Emilija Manojlović Gačić 3 , Gordana Milić 1 & Vesna Dimitrijević Srećković 1
1Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade, Serbia; 2Clinic for Neurosurgery, Clinical Center of Serbia, Belgrade, Serbia; 3Institute of Pathology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Background: Hypopituitarism can be expressed throughout many symptoms and can stay unrecognized for a long time. Xanthogranulomas are extremely rare in sellar region, with prevalence of ~0.6% in reported pituitary tumours and are presented with visual disturbance, hyperprolactinemia, diabetes insipidus and/or hypopituitarism. Its ethiopathogenesis is still not certain, but it can be of primary or systemic cause. It’s almost always diagnosed postoperatively and has good outcome with adequate hormonal substitution.
Case Presentation: A 34-year old man was referred to our Clinic due to a 3-year-history of polymophic symptoms: weight loss, headaches, fatigue, mood changes, loss of libido\.. After endocrinology evaluation, diagnosis of partial hypopituitarism was established and hydrocortisone, levotyroxine and testosterone substitution was ordinated in corresponding doses. Congenital cause was clinically excluded. NMR detected: non-homogenic intra-, supra- and para-sellar mass sized 14×15×8mm, without damage of optic-hyasm and cavernous sinuses, with coincidental finding of pineal gland cyst. After transsphenoidal extirpation, patohistological diagnosis was sellar xanthogranuloma, CD3+, CD20+, IgG4- i CD1a-. Screening on systemic causes was negative. One year after (on therapy) findings of thyroxine and total testosterone were normal, cortisol levels were low normal and control NMR detected possible sellar rest sized 4x8x4mm.
Conclusions: Xanthogranuloma-causing hypopituitarism is not easy to diagnose preoperatively based on NMR appearance. However, since it is known that these lesions occur more frequently in young population, it should be suspected when discovered in young patients presenting with cystic pituitary lesions. These tumours have favorable endocrine outcomes based on its rare post-operative recurrence rate.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more