ECE2019 Poster Presentations Thyroid 2 (70 abstracts)
Predisposition to autoimmune thyroid diseases within a Tunisian multiplex family
Ghazi Chabchoub 1, , Wajdi Sefi 3 , Nadia Charfi 3 , Faten Hadj Kacem 3 , Mouna Mnif 3 , Leila Keskes 1 & Mohamed Abid 3
1Laboratoire de Génétique Moléculaire Humaine, Faculté de Médecine de Sfax, Sfax, Tunisia; 2Caisse national d’assurance maladie (CNAM) Sfax, Sfax, Tunisia; 3Service d’Endocrinologie, Centre Hospitalo-universitaire Hédi Chaker de Sfax., Sfax, Tunisia.
Autoimmune thyroid disease (AITD), including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT), is caused by multiple genetic and environmental factors. The clinical and immunological features of GD and HT are distinct; however, there are multiplex families with both GD and HT. In order to study the genetic susceptibility factors to AITDs, we have followed up 115 control members belonging to a large Tunisian family with a high prevalence of AITDs (Akr family) during 15 years between 1990 to 2005. The follow-up of these control members have showed that 13 subjects (11.3%) developed AITDs. HT was the most frequently seen in 77% of the cases, whereas GD was present in 23% of the cases. One hundred and two members remained controls. High female predominance was noted in the two groups. The mean age of the control subjects group was slightly higher than patients group. The prevalence of positive antithyroglobulin antibody (TgAb) and antithyroperoxydase antibody (TPOAb) was more frequent in patient group (P=0.27 and P=0.23) respectively. The HLA haplotypes was realized in 42% of control members. The most frequent HLA haplotypes that were found were B37, DRB11 and A1. HLA B37 and DRB11 were significantly more frequent for patients (P=0.0001 and P=0.034) respectively. Our study confirms the contribution of the genetic factors in the development of AITDs in ‘Akr’ family and suggested that the members of this family share the same genetic inheritance.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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