ECE2019 Poster Presentations Thyroid 2 (70 abstracts)
Assessment of thyroid functions and thyroid volume in normal pregnant Egyptian females
Ibrahim Elebrashy , Hebat-Allah Kamal Eldein , Hoda Abd-Elstar , Nashwa Ghanem , Shrook Mousa , Maha Assem , Laila Rashed , Mohamed Salit , Maged Abd-Elraoof , Ahmed Dorgham , Ahmed Mansour , Mohamed Mahmoud & Aasem Saif
Cairo University, Cairo, Egypt.
Background and aim: The normal range of thyroid functions during pregnancy differs between ethnic groups. The aim of this work was to assess the thyroid functions in normal pregnant Egyptian females in order to establish a population-specific reference range. Thyroid peroxidase antibodies (TPO Abs) and thyroid volume were also assessed.
Methods: The study included 150 normal pregnant Egyptian females (with no history suggestive of thyroid disease), recruited from Cairo university hospital antenatal care clinic (50 in each trimester), with 40 age-matched non-pregnant females, as a control group. Serum TSH and TPO Abs were measured. Thyroid volume was assessed in both groups by ultrasonography.
Results: TSH ranges were 0.21–1.7, 0.52–3.2 and 0.72–2.6 mIU/l during first, second and third trimesters respectively. The mean TSH level in pregnant females was significantly lower than that of non-pregnant women (1.2±0.7 vs 2.7±0.9 mIU/l, P<0.001). The mean TPO Ab level was significantly higher in the first trimester compared to both second and third trimesters (P<0.001 for both). Thyroid volume of pregnant females was non-significantly higher than that of non-pregnant control subjects (P=0.126). A significant positive correlation was found between thyroid volume and BMI in pregnant females (P<0.001).
Conclusion: Our study established trimester-specific reference ranges for thyroid functions in normal pregnant Egyptian females. A larger population-based study would help to confirm those ranges. Thyroid volume was non-significantly higher than that of non-pregnant control subjects.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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