Endocrine Abstracts

Bone metabolism disorders in hemodialysed patients (HD) involve several humoral factors, of which PTH plays the central role. Leptin is a protein hormon secreted by the adipocytes and related to malnutrition, anemia and bone metabolism disorders in chronic kidney disease patients. The aim of the study was to was to evaluate serum leptin levels and bone metabolism in chronic HD patients depending on body mass index (BMI). This cross section study included 93 HD patients distributed based on BMI in: underweight (n=7), normal weight (n=38), overweight (n=38) and obesity (n=10). Underweight patients had significantly significantly lower leptin level (2.02±1.7 vs 8.62±10.66 vs 32.99±34.52 vs 78.02±51.61, P<0.001), higher PTH level (686.42±1100.43 vs 271.60±321.47 vs 242.0±271.54 vs 254.20±280.68 P<0.001) and higher alkalne phosphatase (156.27±27.13 vs 81.92±44.69 vs 84.50±28.16 vs 66.70±19.27, P<0.001). There were no significant differance in calcium and phosphate level between groups. A significant direct correlation was observed in all groups between leptin level and BMI (P<0.001) and indirect correlation between leptin and PTH level in underweight and obesity group (P<0.05). Hypoleptinemia in chronic HD patients was associated with high PTH and undernutrition.

Keywords: leptin, body mass index, parathyroid hormone, hemodialysis