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Endocrine Abstracts (2019) 63 P588 | DOI: 10.1530/endoabs.63.P588

ECE2019 Poster Presentations Diabetes, Obesity and Metabolism 2 (100 abstracts)

Genetic diagnosis of maturity-onset diabetes of the young (MODY): experience of diabetology-endocrinology department of Oujda’s Mohammed VI university hospital

Asmaa Khlifi , Salma Ben Yakhlef & Hanane Latrech


Diabetology-endocrinology Department of Oujda’s Mohammed VI University Hospital, Oujda, Morocco.


Introduction: Maturity Onset Diabetes of the Young (MODY) is a monogenic form of non-insulin-dependent diabetes that classically presents in a lean individual with non ketotic hyperglycaemia and an autosomal dominant inheritance pattern. The diagnosis remains a challenge and may be made by careful clinical evaluation, but exact sub-typing is possible only by genetic analysis.

Materials and methods: This is a prospective data analysis in the diabetology-endocrinology department of Oujda’s Mohammed VI university hospital during a one year period as part of a research programm covering the Mediterranean region to detect monogenic diabetes among patients suspected to have atypical diabetes. A written informed consent was obtained from all the participants. 20 patients were recruited based on probant clinical evaluation with a positive predictive value (>25%) on the MODY calculator. Saliva samples were used for genetic assays relying on targeted PCR-based enrichment and next generation sequencing.

Results: Almost full records were available for all the patients who were selected; but only 12 had the genetic testing. A MODY 3 and 2 were respectively identified in a 20 and 27 year old patients.

Conclusion: Identification of MODY by medical practitioners is important, as it has both genetic and therapeutic repercussions, which leads to lower diabetic complications and better quality of life.

Volume 63

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

European Society of Endocrinology 

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