Endocrine Abstracts

Microcirculatory disorders play important role in pathogenesis of diabetic vascular complications.

Aim: To study peculiarities of microcirculatory haemostasis (tromboresistance of vessel wall and functional activity of thrombocytes) in adolescents with type 1 diabetes mellitus (T1DM).

Patients and methods: 80 adolescents (42 boys, 38 girls) 11–16 y.o. with T1DM were examined. The duration of the disease was: less than 1 year - in 27 patients (HbAc1 7.1±0.4%) – group 1, from 1 to 5 years - in 23 patients (HbAc1 8.7±1.2%) – group 2, more then 5 years - in 30 patients (HbAc1 10.2±1.1%) – group 3. Control group: 50 healthy adolescents 11–16 y.o. The indexes of tromboresistance of vessel wall (antiaggregating, anticoagulating, antifibrinolytic activity) measured by manjetic method. The indexes of trombocyte aggregation (degree, speed and time of aggregation) measured by laser method with different inductors (ADP, adrenalin, kollagen) and intravascular aggregation were evaluated.

Results: Tromboresistance of vessel wall was normal in group 1 in comparance of control group (P<0.05). Levels of ADP- and adrenalin-stimulating aggregation, intravascular aggregation of thrombocytes were increased in this group (P<0.05). Tromboresistance of vessel wall was decreased in group 2 (P<0.05). Levels of ADP- and kollagen-stimulating aggregation (P<0.05) and intravascular aggregation (P<0.05) were also increased in group 2. Decrease of aggregation time was revealed in this group (P<0.05). Decrease of tromboresistance of vessel wall (P<0.001), increase of all indexes of functional activity of thrombocytes (P<0.05) and intravascular aggregation (P<0.001) were found in patients of group 3 in comparance of control group.

Conclusions: Microcirculatory disorders in adolescents with T1DM correlated with duration of the disease and may demand treatment.