Endocrine Abstracts

Objectives: To analyze the presence of correlation between DHEA-S level and glycemic indices at CGMS of intercellular fluid according to the regularity of menstrual cycle of women with type 1 diabetes mellitus.

Methods: The study of daily dynamics of glucose has been performed with continuous glucose monitoring system (CGMS) Medtronik MINIMED company, the USA. The study involved 155 patients with type 1 diabetes mellitus. The patients were divided into 2 groups: group 1 - women with regular menstrual cycle (n=117), group 2 - women with abnormal menstrual cycle (n=38). The groups were compared in mean age (28.59±7.10 years) and duration of type 1 diabetes mellitus (10.46±7.67 years).

Results: In the first group, significant negative correlations were found between the level of DHEA-S with the duration of the hyperglycemia period (r_s =−0.19), the duration of DM type 1 (r_s =−0.23) and a positive correlation with the duration of the normal glycaemia period (r_s = 0.24). In the second group, significant negative correlations were found between the DHEA-S level and the HbA_1C level (r_s=−0.50), the mean glucose level in the ICF (r_s=−0.40), the maximum glucose level in the ICF (r_s =−0.44) with the duration of the hyperglycemia period (r_s =−0.41) and a positive correlation with the duration of the normal glycaemia period (r_s =0.39).

Conclusions: 1. Regardless of the regularity of the menstrual cycle, hyperglycemia is accompanied by a decrease in the DHEA-S level.

2. Decrease in the DHEA-S level has been noted in the onset of DM type 1 with a regular menstrual cycle.