Endocrine Abstracts

Introduction: Studies demonstrate that non-functioning adrenal incidentalomas are assosiated with increased risk of diabetes mellitus and cardiovascular diseases. Chronic inflammation plays key role in developing type 2 diabetes, as well as cardiovascular diseases.

Aim: The purpose of the study was to evaluate new anthropometric parameters (BAI, LAP, VAI, BRI, ABSI, RFM) and its relationship with inflammation indicators (PLR, MPVLR, SII) among patients with non-functioning adrenal incidentalomas.

Material and methods: 63 patients hospitalized in Endocrinology City Hospital in Piekary in 2014–2017 with non-functioning adrenal incidentalomas were inclued to the study. The exclusion criteria were mainly: other adrenal disorders, decompensated diabetes defined as HBA1C%>7, kidney failure as eGFR<60 ml/min/1.73 m², liver failure as bilirubin>2 mg/dl, INR>1.5 and albumins<3.5 g/dl, severe inflammation, treated cancer disease. Anthropometric parameters were measured in morning hours, biochemical parameters were taken from the patient’s medical record.

Results: The average age was 60 years (±9.9), waist circumference in women was 99.9 cm (±15.3), in men 109.2 cm (±11.2), cortisol concentration at 8 a.m. was 10.7 ug/dl (±3.2), CRP was 2.5 (±4.0). In the studied group, PLR correlated negatively (P<0.05) with VAI (r=−0.4) and LAP. There was also negative correlation observed between VAI and MPVLR (r=−0.3) and VAI and SII (r=−0.3). There was no signifficant correlation (P>0.05) demonstrated between analyzed inflammation indicators and BAI, BRI, ABSI, RFM in the studied group, and no signifficant difference (P>0.05) betweeen analyzed inflammation indicators in group of patients with and without compensated diabetes.

Conclusion: The study indicated that the measurment of VAI and LAP could reflect new inflammaItion indicators in analyzed group of patients with non-functioning adrenal incidentalomas. It is worth to enlarge the studied group to confirm obtained results.