ECE2019 Poster Presentations Thyroid 1 (70 abstracts)
The relationship between thyroid receptor antibody and anti mullerian hormone in Graves’ disease
Keziban Demir 1 , Hakan Kursat 1 , Sevde Yazici 1 , Hamide Pişkinpaşa 2 , Evin Bozkir 2 , Ayşe Esen 2 , Yasemin Akdeniz 2 , Sema Doğanşen 2 , Mehmet Hurşitoğlu 1 , Alev Kural 3 & Meral Mert 2
1University of Healt Science Bakırköy Dr. Sadi Konuk Education and Research Hospital İnternal Medicine Clinic, İSTANBUL, Turkey; 2University of Healt Science Bakırköy Dr. Sadi Konuk Education and Research Hospital Endocrinology and Metabolism Clinic, İSTANBUL, Turkey; 3University of Healt Science Bakırköy Dr. Sadi Konuk Education and Research Hospital Biochemistry Clinic, İSTANBUL, Turkey.
Introduction and Aim: Thyroid dysfunction is the most common autoimmune endocrine disorder in women of reproductive age. Autoimmune thyroid disease is related to menstrual irregularities, anovulation and infertility. Thyroid dysfunction is thought to disrupt follicular growth and maturation. Autoimmunity may have a negative effect on fertility, independent of age. The relation between TSH (Thyroid Stimulant Hormone), thyroid antibodies and AMH (anti-mullerian hormone) is a topic that interesting and resulting different outcomes on last days. Graves is an autoimmune disease. The aim of this study is to investigate whether there is a relationship between TRAB (TSH Receptor Stimulating Antibody) and the primary ovarian reserve indicator AMH in Graves’ disease.
Materials and Methods: Our population includes only women patients which are appeal to endocrinology and internal medicine polyclinics at T.C. Health Ministry Bakirkoy Dr Sadi Konuk Hospital between September 2017 and September 2018. We compare 64 TRAB positive Graves patient with any fertility problem as working group and 51 patient with no known outoimmunity disorder as control group. Sociodemographic data form was applied to all patients included in the study, TSH, sT3, sT4, Anti-TPO, Anti-Tg, TRAB values were noted. 3–4 cc venous blood samples were taken and stored at −80°C to calculate AMH after approach enough patient.
Results: The mean age of the study group was 31.78±7.75 (year) and the mean age of the control group was 31.64±7.71 (year). Age, AMH, fT3, fT4, TSH, Anti-TPO, Anti-Tg results were compared between control and working group. No significiant difference is detected between age and AMH on two groups. On working group there is no significant difference betweeen TRAB, TSH, Anti TPO, Anti TG, fT3, fT4 values and AMH value. On control group there is no significant difference betweeen TRAB, TSH, Anti TPO, Anti TG, fT3, fT4 values and AMH value. Result: In our study, there was no significant relationship between the level of TRAB and AMH, a raised antibody in Graves’ Disease. We also showed that the levels of Anti-TPO and Anti-Tg were not correlated with AMH levels. Among the reasons for this, the number of patients, working method, disease activation periods can be among the effective factors. More Large patient group and prospective comparison studies are needed.
Keywords: Graves Disease, Anti Mullerian Hormone, TSH Receptor Stimulating Antibody, ovarian failure
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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