ECE2019 Poster Presentations Reproductive Endocrinology 1 (40 abstracts)
The natural course of normal weight women with polycystic ovary syndrome: an insight into metabolic changes of a large Caucasian cohort
Sarantis Livadas 1 , Djuro Macut 2 , Christina Bothou 3 , Justyna Kuliczkowska-Płaksej 4 , Andromahi Vryonidou 5 , Jelica Bjekic-Macut 6 , Zadalla Mouslech 7 , Andrzej Milewicz 4 & Dimitrios Panidis 8
1Endocrine Unit, Metropolitan Hospital, Athens, Greece; 2Clinic of Endocrinology, Diabetes and Metabolic Diseases, Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 3Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital of Zurich, Zurich, Switzerland; 4Department of Endocrinology, Diabetology and Isotope Therapy, University of Medicine, Wroclaw, Poland; 5Department of Endocrinology and Diabetes, Hellenic Red Cross Hospital, Athens, Greece; 6Department of Endocrinology, UMC Bežanijska kosa, Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 71st Medical Propedeutic Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece; 8Gynaecological Endocrinology Infirmary of the Second Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Objective: Polycystic ovary syndrome (PCOS) is hypothesized to originate in foetal life, while its long-term consequences extend beyond menopause. However, the natural course of the disorder has not as yet been elucidated, and recent data suggest differences in the evolution of PCOS according to a woman’s weight. We aimed to define the evolution of normal-weight Caucasian women with PCOS through the years.
Design: Cross-sectional case control study
Methods: A total of 763 normal-weight women with PCOS (Rotterdam) and 376 age- and BMI-matched controls were included. The study group was further divided into three age groups, representing women post-adolescence, of reproductive age, and of late reproductive age to menopause. All the subjects were assessed clinically, biochemically, hormonally, and by pelvic ultrasound.
Results: Waist circumference, lipids, androgens and insulin resistance index (HOMA-IR), and ovarian volume were significantly higher in the PCOS group compared to controls. Age subgroup analysis showed that androgens remained significantly higher among PCOS and controls, whereas lipid levels and HOMA-IR were comparable between PCOS and controls in all age groups. A significant negative association of age with waist circumference, androgens, insulin, and HOMA-IR was revealed. Multiple regression analysis disclosed significant negative association of HOMA-IR with age (r:−0.123) and a positive association with BMI (r: 0.105) and DHEAS (r: 0.175).
Conclusions: Lipids, androgens, and insulin resistance are gradually improved in an age-dependent manner in normal weight PCOS women and controls. It seems evident that if PCOS women retain their normal weight over the years, their cardiovascular risk is significantly improved.
Volume 63
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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