Endocrine Abstracts

Aim: To study the morphofunctional state of the myocardium in young people with diabetes mellitus 1 using magnetic resonance imaging (MRI) technology.

Material and methods: 38 patients (14 men, 24 women), aged 18–36 years old, with an experience of type 1 diabetes from 5 to 16 years old were underwent contrastive mri of the heart. The exclusion criteria were: pronounced electrolyte disorders in the blood, dysproteinemia, chronic liver and kidney failure – glomerular filtration rate (EPI) −60 ml/min/1.73 m², thyroid dysfunction, obesity (body mass index −30 kg/m²), diagnosed cardiovascular diseases, contraindications for mri. The indicators of functional changes in the left ventricle (circular strain, strain relaxation index – SRI), peak early diastolic strain (PSRDS) were obtained and the accumulation of the contrast agent in the delayed period were assessed.

Results: The obtained results of strain, SRI, PSRDS do not allow to exclude the presence of functional changes in the myocardium of the left ventricle. In 42.11%, zones of accumulation of the contrast agent were visualized in the delayed period (insignificant – 28.95% and moderate accumulation – 13.16%), mainly by the endocardium of the cardiac apparatus (mitral and tricuspid), and in one observation (2.9%) – in combination with unexpressed diffuse heterogeneity of the myocardium of the left ventricle.

Conclusion: MRI of the heart is a promising direction in the assessment of early morphofunctional changes in the structure of the myocardium, which will probably make it possible to predict life-threatening changes in the heart muscle in young patients with type 1 diabetes.