ECE2019 Poster Presentations Diabetes, Obesity and Metabolism 1 (104 abstracts)
Predictors of incident hypertension in healthy, non-diabetic postmenopausal women with normal renal function
Kimon Stamatelopoulos 1 , Michael Apostolakis 2 , Areti Augoulea 2 , Stavroula A Paschou 2 , Eleni Armeni 2 , Konstantinos Panoulis 2 , Panagiotis Bakas 2 , Georgios Georgiopoulos 1 , George Kaparos 3 , Dimitrios Rizos 3 & Irene Lambrinoudaki 2
1Vascular Laboratory, Department of Clinical Therapeutics, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece; 2Second Department of Obstetrics and Gynecology, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece; 3Biochemical Laboratory, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Introduction: The aim of this study was to investigate the incidence of hypertension and to identify potential risk factors in healthy, non-diabetic recently postmenopausal Greek women with normal renal function.
Patients and methods: In this retrospective cohort study, we evaluated 141 recently postmenopausal women at baseline and annually thereafter (follow-up time: 1 to 8 years). Blood samples were obtained and ultrasound evaluations were performed at baseline. A detailed medical history, anthropometric parameters, blood pressure and cardiovascular risk factors were recorded for every woman at each visit. Incident hypertension was defined as first occurrence of systolic or diastolic hypertension, measured at 2 different visits within 2 months, or initiation of antihypertensive medication.
Results: Incident hypertension was diagnosed in 30 out of 141 women (21.3%). Median time to incident hypertension was 3.5 years after menopause. Obesity, elevated cholesterol and triglyceride levels, insulin resistance and parity were positively associated with incident hypertension. In multivariate analysis, however, obesity and insulin resistance were the only statistically significant variables associated with more than 3fold and 2fold respectively increased risk of incident hypertension (obesity: OR=3.746, P value=0.019, HOMA-IR: OR=1.988, P-value=0.043).
Conclusions: A large proportion of women entering the menopause present incident hypertension and this is mostly associated with obesity and insulin resistance.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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